Technology Process of d29-(3R)-3-benzhydryloxy-1-(2-benzo[1,3]dioxol-5-yl-ethyl)-piperidine
There total 11 articles about d29-(3R)-3-benzhydryloxy-1-(2-benzo[1,3]dioxol-5-yl-ethyl)-piperidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
deuterated Raney nickel;
at 70 - 100 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 5 steps
2.1: lithium aluminium deuteride / tetrahydrofuran
3.1: trifluoroacetic anhydride / tetrahydrofuran / 3 h / -78 °C
3.2: 20.25 h / -78 °C / Heating / reflux
3.3: 3 h / Heating / reflux
4.1: 2 h / Heating / reflux; Neat (no solvent)
5.1: deuterated Raney nickel / 18 h / 70 - 100 °C
With
lithium aluminium deuteride; deuterated Raney nickel; trifluoroacetic anhydride;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride
3.1: lithium aluminium deuteride / tetrahydrofuran
4.1: trifluoroacetic anhydride / tetrahydrofuran / 3 h / -78 °C
4.2: 20.25 h / -78 °C / Heating / reflux
4.3: 3 h / Heating / reflux
5.1: 2 h / Heating / reflux; Neat (no solvent)
6.1: deuterated Raney nickel / 18 h / 70 - 100 °C
With
thionyl chloride; lithium aluminium deuteride; deuterated Raney nickel; trifluoroacetic anhydride;
In
tetrahydrofuran;
