(S)-2-((2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-phenyl-propionic acid 4-phenylacetoxy-benzyl ester

Base Information

• Chemical Name: (S)-2-((2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-phenyl-propionic acid 4-phenylacetoxy-benzyl ester
• CAS No.: 330970-68-8
• Molecular Formula: C₃₃H₃₈N₂O₈
• Molecular Weight: 590.673

Synonyms:(S)-2-((2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-phenyl-propionic acid 4-phenylacetoxy-benzyl ester

Chemical Property of (S)-2-((2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-phenyl-propionic acid 4-phenylacetoxy-benzyl ester

Chemical Property:

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Technology Process of (S)-2-((2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-phenyl-propionic acid 4-phenylacetoxy-benzyl ester

There total 4 articles about (S)-2-((2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-phenyl-propionic acid 4-phenylacetoxy-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Boc-Thr-OH (2592-18-9) + (S)-2-Amino-3-phenyl-propionic acid 4-phenylacetoxy-benzyl ester; compound with trifluoro-acetic acid → (S)-2-((2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-phenyl-propionic acid 4-phenylacetoxy-benzyl ester (330970-68-8)

Guidance literature:

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1002/1521-3765(20020802)8:15<3362::AID-CHEM3362>3.0.CO;2-0

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → (S)-2-((2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-phenyl-propionic acid 4-phenylacetoxy-benzyl ester (330970-68-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: DIC; DMAP

1.2: HCl / diethyl ether

2.1: EEDQ

With dmap; dacarbazine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline;

DOI:10.1002/1521-3773(20010119)40:2<369::AID-ANIE369>3.0.CO;2-7

Reference yield:

4-(hydroxymethyl)phenyl 2-phenylacetate (192999-56-7) → (S)-2-((2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-phenyl-propionic acid 4-phenylacetoxy-benzyl ester (330970-68-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: DIC; DMAP

1.2: HCl / diethyl ether

2.1: EEDQ

With dmap; dacarbazine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline;

DOI:10.1002/1521-3773(20010119)40:2<369::AID-ANIE369>3.0.CO;2-7

upstream raw materials:

Boc-Thr-OH

(S)-2-Amino-3-phenyl-propionic acid 4-phenylacetoxy-benzyl ester

N-tert-butoxycarbonyl-L-phenylalanine

4-(hydroxymethyl)phenyl 2-phenylacetate

Downstream raw materials:

(4-hydroxyphenyl)methanol

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