methyl N-[N-(tert-butyloxycarbonyl)-L-(3-isopropyloxy-4-methoxyphenylalanyl)]-L-4-fluoro-3-nitrophenylalaninate

Base Information

Chemical Name:methyl N-[N-(tert-butyloxycarbonyl)-L-(3-isopropyloxy-4-methoxyphenylalanyl)]-L-4-fluoro-3-nitrophenylalaninate
CAS No.:244769-36-6
Molecular Formula:C₂₈H₃₆FN₃O₉
Molecular Weight:577.607
Hs Code.:

Synonyms:methyl N-[N-(tert-butyloxycarbonyl)-L-(3-isopropyloxy-4-methoxyphenylalanyl)]-L-4-fluoro-3-nitrophenylalaninate

Suppliers and Price of methyl N-[N-(tert-butyloxycarbonyl)-L-(3-isopropyloxy-4-methoxyphenylalanyl)]-L-4-fluoro-3-nitrophenylalaninate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl N-[N-(tert-butyloxycarbonyl)-L-(3-isopropyloxy-4-methoxyphenylalanyl)]-L-4-fluoro-3-nitrophenylalaninate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl N-[N-(tert-butyloxycarbonyl)-L-(3-isopropyloxy-4-methoxyphenylalanyl)]-L-4-fluoro-3-nitrophenylalaninate

There total 6 articles about methyl N-[N-(tert-butyloxycarbonyl)-L-(3-isopropyloxy-4-methoxyphenylalanyl)]-L-4-fluoro-3-nitrophenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (S)-N-(tert-butyloxycarbonyl)-4-fluoro-3-nitrophenylalanine

: 244769-35-5
L-methyl 3-isopropyloxy-4-methoxyphenylalaninate

: 244769-36-6
methyl N-[N-(tert-butyloxycarbonyl)-L-(3-isopropyloxy-4-methoxyphenylalanyl)]-L-4-fluoro-3-nitrophenylalaninate

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 1.33333h;
DOI:10.1021/jo990432w

Reference yield:

: 3-(3-isopropoxy-4-methoxy-phenyl)-propionic acid

: 244769-36-6
methyl N-[N-(tert-butyloxycarbonyl)-L-(3-isopropyloxy-4-methoxyphenylalanyl)]-L-4-fluoro-3-nitrophenylalaninate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / tetrahydrofuran / 1 h / -78 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 84 percent / tetrahydrofuran; hexane / -78 - 20 °C

3.1: KHMDS / tetrahydrofuran; toluene / 0.5 h / -78 °C

3.2: 83 percent / trisyl azide / tetrahydrofuran; toluene / 0.03 h / -78 °C

4.1: MeMgBr / diethyl ether / 0.03 h / 0 °C

4.2: 96 percent / diethyl ether / 0.17 h / 0 °C

5.1: 99 percent / hydrogen / Pd/C / methanol / 1 h

6.1: 90 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 1.33 h / 20 °C

With n-butyllithium; methylmagnesium bromide; hydrogen; potassium hexamethylsilazane; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; toluene; 1.1: Acylation / 2.1: Metallation / 2.2: Substitution / 3.1: Metallation / 3.2: Substitution / 4.1: Substitution / 4.2: Substitution / 5.1: Hydrogenolysis / 6.1: coupling;
DOI:10.1021/jo990432w

Reference yield:

: 244769-34-4
(2S)-methyl 2-azido-3-(3-isopropyloxy-4-methoxyphenyl)propionate

: 244769-36-6
methyl N-[N-(tert-butyloxycarbonyl)-L-(3-isopropyloxy-4-methoxyphenylalanyl)]-L-4-fluoro-3-nitrophenylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / hydrogen / Pd/C / methanol / 1 h

2: 90 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 1.33 h / 20 °C

With hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane; 1: Hydrogenolysis / 2: coupling;
DOI:10.1021/jo990432w