8-chloro-5-(2-(piperidin-1-yl)ethoxy)-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine

Base Information

Chemical Name:8-chloro-5-(2-(piperidin-1-yl)ethoxy)-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine
CAS No.:1381954-43-3
Molecular Formula:C₂₃H₂₃ClF₃N₃O₂
Molecular Weight:465.903
Hs Code.:

Synonyms:8-chloro-5-(2-(piperidin-1-yl)ethoxy)-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine

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Chemical Property of 8-chloro-5-(2-(piperidin-1-yl)ethoxy)-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine

Chemical Property:

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Technology Process of 8-chloro-5-(2-(piperidin-1-yl)ethoxy)-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine

There total 7 articles about 8-chloro-5-(2-(piperidin-1-yl)ethoxy)-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 461-82-5
4-(trifluoromethoxy)aniline

: 1381954-68-2
2,8-dichloro-5-(2-(piperidin-1-yl)ethoxy)quinoline

: 1381954-43-3
8-chloro-5-(2-(piperidin-1-yl)ethoxy)-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tert-butyl alcohol; at 90 ℃; for 20h;

Reference yield:

: 1381954-62-6
2-chloro-5-(2-piperidinoethoxy)aniline

: 1381954-43-3
8-chloro-5-(2-(piperidin-1-yl)ethoxy)-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone; water / 2 h / 0 - 20 °C

2: aluminum (III) chloride / chlorobenzene / 2 h / 125 °C

3: trichlorophosphate; triethylamine hydrochloride / acetonitrile / 3 h / 120 °C

4: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tert-butyl alcohol / 20 h / 90 °C

With aluminum (III) chloride; palladium diacetate; triethylamine hydrochloride; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trichlorophosphate; In water; chlorobenzene; acetone; acetonitrile; tert-butyl alcohol;

Reference yield:

: 610-78-6
3-nitro-4-chlorophenol

: 1381954-43-3
8-chloro-5-(2-(piperidin-1-yl)ethoxy)-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 h / 80 °C

2: tin(II) chloride dihdyrate; ethanol / 19 h / 60 °C

3: potassium carbonate / acetone; water / 2 h / 0 - 20 °C

4: aluminum (III) chloride / chlorobenzene / 2 h / 125 °C

5: trichlorophosphate; triethylamine hydrochloride / acetonitrile / 3 h / 120 °C

6: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tert-butyl alcohol / 20 h / 90 °C

With aluminum (III) chloride; tin(II) chloride dihdyrate; ethanol; palladium diacetate; triethylamine hydrochloride; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium iodide; trichlorophosphate; In water; N,N-dimethyl-formamide; chlorobenzene; acetone; acetonitrile; tert-butyl alcohol;