Podophyllotoxin, derivative of

Base Information

• Chemical Name: Podophyllotoxin, derivative of
• CAS No.: 155252-34-9
• Molecular Formula: C₂₂H₂₁N₃O₇
• Molecular Weight: 439.425
• Mol file: 155252-34-9.mol

Synonyms:4β-azido-4-deoxypodophyllotoxin

Chemical Property of Podophyllotoxin, derivative of

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Podophyllotoxin, derivative of

There total 9 articles about Podophyllotoxin, derivative of which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

epipodophyllotoxin (4375-07-9) → 4β-azido-4-deoxypodophyllotoxin (155252-34-9)

Guidance literature:

With sodium azide; trifluoroacetic acid; In chloroform; at 20 ℃;

Reference yield: 91.0%

podofilox (518-28-5) → 4β-azido-4-deoxypodophyllotoxin (155252-34-9)

Guidance literature:

With sodium azide; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 5h;

DOI:10.1080/10286020.2014.913578

Reference yield: 85.0%

podofilox (518-28-5) → 4β-azido-4-deoxypodophyllotoxin (155252-34-9) + 4'-O-trimethyl-4-azido-4-desoxypodophyllotoxin (155325-17-0)

Guidance literature:

With tris-(2-chloro-ethyl)-amine; boron trifluoride diethyl etherate; In dichloromethane; at -10 ℃; for 1h; Yields of byproduct given;

DOI:10.1080/00397919908086197

upstream raw materials:

podofilox

9-Chloro-9-desoxypodophyllotoxin

Methanesulfonic acid (5R,5aR,8aR,9R)-8-oxo-9-(3,4,5-trimethoxy-phenyl)-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl ester

epipodophyllotoxin

Downstream raw materials:

4β-(4-methoxylbenzimidoyl)-4-deoxypodophyllotoxin

4β-(4-benzimidoyl)-4-deoxypodophyllotoxin

4β-(4-bromobenzylamino)-4-deoxypodophyllotoxin

4β-(4-chlorobenzylamino)-4-deoxypodophyllotoxin