(1-(2-bromophenyl)-3-(4-chlorophenyl)propa-1,2-dien-1-yl)diphenylphosphine oxide

Base Information

• Chemical Name: (1-(2-bromophenyl)-3-(4-chlorophenyl)propa-1,2-dien-1-yl)diphenylphosphine oxide
• CAS No.: 1609661-63-3
• Molecular Formula: C₂₇H₁₉BrClOP
• Molecular Weight: 505.778
• Mol file: 1609661-63-3.mol

Synonyms:(1-(2-bromophenyl)-3-(4-chlorophenyl)propa-1,2-dien-1-yl)diphenylphosphine oxide

Chemical Property of (1-(2-bromophenyl)-3-(4-chlorophenyl)propa-1,2-dien-1-yl)diphenylphosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-(2-bromophenyl)-3-(4-chlorophenyl)propa-1,2-dien-1-yl)diphenylphosphine oxide

There total 2 articles about (1-(2-bromophenyl)-3-(4-chlorophenyl)propa-1,2-dien-1-yl)diphenylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H10BrClO (1609661-91-7) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → (1-(2-bromophenyl)-3-(4-chlorophenyl)propa-1,2-dien-1-yl)diphenylphosphine oxide (1609661-63-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; at -78 - 20 ℃; for 4h;

DOI:10.1039/c4cc00374h

Reference yield:

1-Bromo-2-iodobenzene (583-55-1) + 1-(4-chlorophenyl)prop-2-yn-1-ol (29805-11-6) → (1-(2-bromophenyl)-3-(4-chlorophenyl)propa-1,2-dien-1-yl)diphenylphosphine oxide (1609661-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 4 h / -78 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; 1: |Sonogashira Cross-Coupling;

DOI:10.1039/c4cc00374h

Reference yield: 81.0%

2-phenylethynylphenol (92151-73-0) + (1-(2-bromophenyl)-3-(4-chlorophenyl)propa-1,2-dien-1-yl)diphenylphosphine oxide (1609661-63-3) → (6-(4-chlorophenyl)-12-phenyl-6H-naphtho[2,3-c]chromen-7-yl)diphenylphosphine oxide (1609662-56-7)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; at 100 ℃; regioselective reaction;

DOI:10.1039/c4cc00374h

upstream raw materials:

1-Bromo-2-iodobenzene

1-(4-chlorophenyl)prop-2-yn-1-ol

C₁₅H₁₀BrClO

chloro-diphenylphosphine

Downstream raw materials:

(6-(4-chlorophenyl)-12-phenyl-6H-naphtho[2,3-c]chromen-7-yl)diphenylphosphine oxide