(3R,3aS,6aR,9aR,9bS)-3-{[oxy]methyl}-6,9-dimethylenedecahydroazuleno[4,5-b]furan-2(9bH)-one

Base Information

Chemical Name:(3R,3aS,6aR,9aR,9bS)-3-{[oxy]methyl}-6,9-dimethylenedecahydroazuleno[4,5-b]furan-2(9bH)-one
CAS No.:272781-01-8
Molecular Formula:C₁₅H₂₀O₃
Molecular Weight:248.322
Hs Code.:

Synonyms:(3R,3aS,6aR,9aR,9bS)-3-{[oxy]methyl}-6,9-dimethylenedecahydroazuleno[4,5-b]furan-2(9bH)-one

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Chemical Property of (3R,3aS,6aR,9aR,9bS)-3-{[oxy]methyl}-6,9-dimethylenedecahydroazuleno[4,5-b]furan-2(9bH)-one

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Technology Process of (3R,3aS,6aR,9aR,9bS)-3-{[oxy]methyl}-6,9-dimethylenedecahydroazuleno[4,5-b]furan-2(9bH)-one

There total 3 articles about (3R,3aS,6aR,9aR,9bS)-3-{[oxy]methyl}-6,9-dimethylenedecahydroazuleno[4,5-b]furan-2(9bH)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 74299-48-2,93219-83-1,477-43-0
dehydrocostus lactone

: 96552-47-5
(11R)-11,13-dihydroxy-guaiane-4⁽¹⁵⁾,10⁽¹⁴⁾-dien-6,12-olide

: 272781-01-8
(3R,3aS,6aR,9aR,9bS)-3-{[oxy]methyl}-6,9-dimethylenedecahydroazuleno[4,5-b]furan-2(9bH)-one

: (11S)-13-hydroxy-guaiane-4⁽¹⁵⁾,10⁽¹⁴⁾-dien-6,12-olide

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium carbonate; at 90 - 95 ℃; for 168h;
DOI:10.1021/jf0005364

Reference yield:

: 74299-48-2,93219-83-1,477-43-0
dehydrocostus lactone

: 272781-01-8
(3R,3aS,6aR,9aR,9bS)-3-{[oxy]methyl}-6,9-dimethylenedecahydroazuleno[4,5-b]furan-2(9bH)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 48 h / 20 °C

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 6 h / 0 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water;
DOI:10.1021/acs.jafc.9b03098