1,1-Bis(4-fluorophenyl)prop-2-yn-1-ol

Base Information

Chemical Name:1,1-Bis(4-fluorophenyl)prop-2-yn-1-ol
CAS No.:357-77-7
Molecular Formula:C15H10 F2 O
Molecular Weight:244.241
Hs Code.:2906299090
DSSTox Substance ID:DTXSID60570411
Nikkaji Number:J1.461.528H
Wikidata:Q82457832
Mol file:357-77-7.mol

Synonyms:1,1-Bis(4-fluorophenyl)prop-2-yn-1-ol;357-77-7;1,1-Di(4-fluorophenyl)-2-propyn-1-ol;SCHEMBL202283;1,1-BIS-(4-FLUORO-PHENYL)-PROP-2-YN-1-OL;DTXSID60570411;AKOS016846118

Suppliers and Price of 1,1-Bis(4-fluorophenyl)prop-2-yn-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1,1-Bis(4-fluorophenyl)prop-2-yn-1-ol 95+%
1g
$ 589.00

Chemenu
1,1-bis(4-fluorophenyl)prop-2-yn-1-ol 95%
1g
$ 556.00

American Custom Chemicals Corporation
1,1-BIS-(4-FLUORO-PHENYL)-PROP-2-YN-1-OL 95.00%
1G
$ 843.15

American Custom Chemicals Corporation
1,1-BIS-(4-FLUORO-PHENYL)-PROP-2-YN-1-OL 95.00%
100MG
$ 635.25

Alichem
1,1-Bis(4-fluorophenyl)prop-2-yn-1-ol
1g
$ 513.60

Total 7 raw suppliers

Chemical Property of 1,1-Bis(4-fluorophenyl)prop-2-yn-1-ol

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.577
Boiling Point:325.666°C at 760 mmHg
PKA:11.45±0.29(Predicted)
Flash Point:150.758°C
PSA：20.23000
Density:1.269g/cm³
LogP:2.83390
Storage Temp.:2-8°C
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:244.06997126
Heavy Atom Count:18
Complexity:295

Purity/Quality:

98%min ^*data from raw suppliers

1,1-Bis(4-fluorophenyl)prop-2-yn-1-ol 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C#CC(C1=CC=C(C=C1)F)(C2=CC=C(C=C2)F)O

Technology Process of 1,1-Bis(4-fluorophenyl)prop-2-yn-1-ol

There total 7 articles about 1,1-Bis(4-fluorophenyl)prop-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 345-92-6
4,4'-Difluorobenzophenone

: 1066-54-2
trimethylsilylacetylene

: 357-77-7
1,1-bis(4-fluorophenyl)prop-2-yn-1-ol

Guidance literature:: trimethylsilylacetylene; With n-butyllithium; In tetrahydrofuran; at -10 ℃; for 1h;

4,4'-Difluorobenzophenone; In tetrahydrofuran; at -10 ℃; for 5h;

With methanol; potassium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

Reference yield: 71.0%

: 65032-27-1
ethynylmagnesium chloride

: 345-92-6
4,4'-Difluorobenzophenone

: 357-77-7
1,1-bis(4-fluorophenyl)prop-2-yn-1-ol

Guidance literature:: ethynylmagnesium chloride; 4,4'-Difluorobenzophenone; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; Saturated solution;
DOI:10.3762/bjoc.5.25

Reference yield: 43.0%

: calcium carbide

: 345-92-6
4,4'-Difluorobenzophenone

: 1446174-98-6
1,1,4,4-tetrakis(4-fluorophenyl)but-2-yne-1,4-diol

: 357-77-7
1,1-bis(4-fluorophenyl)prop-2-yn-1-ol

Guidance literature:: calcium carbide; With potassium hydroxide; for 0.5h; Milling; Sealed tube;

4,4'-Difluorobenzophenone; for 3h; Milling; Sealed tube;
DOI:10.1002/anie.201905670