1'-ethyl-4,5-dihydro-4',6'-dimethyl-5-(4-chlorobenzylidene)spiro[furan-2(3H),3'-[3H]indol]-2'(1'H)-one

Base Information

Chemical Name:1'-ethyl-4,5-dihydro-4',6'-dimethyl-5-(4-chlorobenzylidene)spiro[furan-2(3H),3'-[3H]indol]-2'(1'H)-one
CAS No.:1354577-28-8
Molecular Formula:C₂₂H₂₂ClNO₂
Molecular Weight:367.875
Hs Code.:

Synonyms:1'-ethyl-4,5-dihydro-4',6'-dimethyl-5-(4-chlorobenzylidene)spiro[furan-2(3H),3'-[3H]indol]-2'(1'H)-one

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Chemical Property of 1'-ethyl-4,5-dihydro-4',6'-dimethyl-5-(4-chlorobenzylidene)spiro[furan-2(3H),3'-[3H]indol]-2'(1'H)-one

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Technology Process of 1'-ethyl-4,5-dihydro-4',6'-dimethyl-5-(4-chlorobenzylidene)spiro[furan-2(3H),3'-[3H]indol]-2'(1'H)-one

There total 5 articles about 1'-ethyl-4,5-dihydro-4',6'-dimethyl-5-(4-chlorobenzylidene)spiro[furan-2(3H),3'-[3H]indol]-2'(1'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1354577-20-0
C₂₂H₂₀ClNO₂

: 1354577-28-8
1'-ethyl-4,5-dihydro-4',6'-dimethyl-5-(4-chlorobenzylidene)spiro[furan-2(3H),3'-[3H]indol]-2'(1'H)-one

Guidance literature:: With sodium tetrahydroborate; nickel dichloride; In methanol; 1,2-dimethoxyethane; at 20 ℃; for 0.5h;
DOI:10.1002/adsc.201100034

Reference yield:

: 65650-09-1
5-(4-chloro-benzoyl)-furan-2-carboxylic acid

: 1354577-28-8
1'-ethyl-4,5-dihydro-4',6'-dimethyl-5-(4-chlorobenzylidene)spiro[furan-2(3H),3'-[3H]indol]-2'(1'H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 3 h / Reflux

2: triethylamine / tetrahydrofuran

3: sodium tetrahydroborate / methanol / 20 °C

4: copper(ll) sulfate pentahydrate; acetic acid / toluene / 5 h / 100 °C

5: sodium tetrahydroborate; nickel dichloride / methanol; 1,2-dimethoxyethane / 0.5 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; copper(ll) sulfate pentahydrate; acetic acid; triethylamine; nickel dichloride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; toluene; 4: Friedel Crafts alkylation;
DOI:10.1002/adsc.201100034

Reference yield:

: 1311388-80-3
C₁₂H₆Cl₂O₃

: 1354577-28-8
1'-ethyl-4,5-dihydro-4',6'-dimethyl-5-(4-chlorobenzylidene)spiro[furan-2(3H),3'-[3H]indol]-2'(1'H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran

2: sodium tetrahydroborate / methanol / 20 °C

3: copper(ll) sulfate pentahydrate; acetic acid / toluene / 5 h / 100 °C

4: sodium tetrahydroborate; nickel dichloride / methanol; 1,2-dimethoxyethane / 0.5 h / 20 °C

With sodium tetrahydroborate; copper(ll) sulfate pentahydrate; acetic acid; triethylamine; nickel dichloride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; toluene; 3: Friedel Crafts alkylation;
DOI:10.1002/adsc.201100034