methyl (3S)-3-[(1R)-N-(4-methoxybenzyl)-1-(4-methoxyphenyl)ethylamino]-3-phenylpropanoate

Base Information

Chemical Name:methyl (3S)-3-[(1R)-N-(4-methoxybenzyl)-1-(4-methoxyphenyl)ethylamino]-3-phenylpropanoate
CAS No.:281664-28-6
Molecular Formula:C₂₇H₃₁NO₄
Molecular Weight:433.547
Hs Code.:

Synonyms:methyl (3S)-3-[(1R)-N-(4-methoxybenzyl)-1-(4-methoxyphenyl)ethylamino]-3-phenylpropanoate

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Chemical Property of methyl (3S)-3-[(1R)-N-(4-methoxybenzyl)-1-(4-methoxyphenyl)ethylamino]-3-phenylpropanoate

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Technology Process of methyl (3S)-3-[(1R)-N-(4-methoxybenzyl)-1-(4-methoxyphenyl)ethylamino]-3-phenylpropanoate

There total 3 articles about methyl (3S)-3-[(1R)-N-(4-methoxybenzyl)-1-(4-methoxyphenyl)ethylamino]-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 103-26-4,1754-62-7
Methyl cinnamate

: 281664-25-3
(R)-(+)-N-4-Methoxybenzyl-1-(4-methoxyphenyl)ethylamine

: 281664-28-6
methyl (3S)-3-[(1R)-N-(4-methoxybenzyl)-1-(4-methoxyphenyl)ethylamino]-3-phenylpropanoate

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 ℃;
DOI:10.1080/00397910008087223

Reference yield:

: 6298-96-0,22038-86-4,35600-82-9,41851-59-6
1(R)-(4-methoxyphenyl)-ethylamine

: 281664-28-6
methyl (3S)-3-[(1R)-N-(4-methoxybenzyl)-1-(4-methoxyphenyl)ethylamino]-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / potassium carbonate / various solvent(s) / 65 °C

2: 44 percent / n-BuLi / tetrahydrofuran / -78 °C

With n-butyllithium; potassium carbonate; In tetrahydrofuran; 2: Michael addition;
DOI:10.1080/00397910008087223

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 281664-28-6
methyl (3S)-3-[(1R)-N-(4-methoxybenzyl)-1-(4-methoxyphenyl)ethylamino]-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / potassium carbonate / various solvent(s) / 65 °C

2: 44 percent / n-BuLi / tetrahydrofuran / -78 °C

With n-butyllithium; potassium carbonate; In tetrahydrofuran; 2: Michael addition;
DOI:10.1080/00397910008087223