1-((1S,4R,5S)-5-Hydroxy-4-hydroxymethyl-cyclohex-2-enyl)-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-((1S,4R,5S)-5-Hydroxy-4-hydroxymethyl-cyclohex-2-enyl)-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:1055721-43-1
Molecular Formula:C₁₂H₁₆N₂O₄
Molecular Weight:252.27
Hs Code.:

Synonyms:1-((1S,4R,5S)-5-Hydroxy-4-hydroxymethyl-cyclohex-2-enyl)-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-((1S,4R,5S)-5-Hydroxy-4-hydroxymethyl-cyclohex-2-enyl)-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-((1S,4R,5S)-5-Hydroxy-4-hydroxymethyl-cyclohex-2-enyl)-5-methyl-1H-pyrimidine-2,4-dione

There total 5 articles about 1-((1S,4R,5S)-5-Hydroxy-4-hydroxymethyl-cyclohex-2-enyl)-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 677758-05-3
5-methyl-1-(2-phenyl-4a,7,8,8a-tetrahydro-4H-benzo[1,3]dioxin-7-yl)-1H-pyrimidine-2,4-dione

: 1055721-43-1
1-((1S,4R,5S)-5-Hydroxy-4-hydroxymethyl-cyclohex-2-enyl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With trifluoroacetic acid; In water; for 40h;
DOI:10.1016/j.tet.2003.12.052

Reference yield:

: C₁₉H₂₀N₂O₅

: 1055721-43-1
1-((1S,4R,5S)-5-Hydroxy-4-hydroxymethyl-cyclohex-2-enyl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With ammonia; In methanol;

Reference yield:

: (+/-)-(4aR,7R,8aS)-2-phenyl-4a,7,8,8a-tetrahydro-4H-benzo[d][1,3]dioxin-7-ol

: 1055721-43-1
1-((1S,4R,5S)-5-Hydroxy-4-hydroxymethyl-cyclohex-2-enyl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / DMAP; pyridine / 20 °C

2: porcine liver esterase; phosphate buffer / H₂O; 2-methyl-propan-2-ol / 10 h / 20 °C / pH 7.5

3: 60 percent / trifluoroacetic acid / H₂O / 40 h

With pyridine; porcine liver esterase; dmap; phosphate buffer; trifluoroacetic acid; In water; tert-butyl alcohol; 3: Mitsunobu reaction;
DOI:10.1016/j.tet.2003.12.052