ethyl 2,4(1H,3H)-dioxo-1-(2-aminobenzyl)-5-methyl-6-(4-methoxyphenyl)thieno[2,3-d]pyrimidine-3-acetate

Base Information

Chemical Name:ethyl 2,4(1H,3H)-dioxo-1-(2-aminobenzyl)-5-methyl-6-(4-methoxyphenyl)thieno[2,3-d]pyrimidine-3-acetate
CAS No.:165809-18-7
Molecular Formula:C₂₅H₂₅N₃O₅S
Molecular Weight:479.557
Hs Code.:

Synonyms:ethyl 2,4(1H,3H)-dioxo-1-(2-aminobenzyl)-5-methyl-6-(4-methoxyphenyl)thieno[2,3-d]pyrimidine-3-acetate

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Chemical Property of ethyl 2,4(1H,3H)-dioxo-1-(2-aminobenzyl)-5-methyl-6-(4-methoxyphenyl)thieno[2,3-d]pyrimidine-3-acetate

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Technology Process of ethyl 2,4(1H,3H)-dioxo-1-(2-aminobenzyl)-5-methyl-6-(4-methoxyphenyl)thieno[2,3-d]pyrimidine-3-acetate

There total 6 articles about ethyl 2,4(1H,3H)-dioxo-1-(2-aminobenzyl)-5-methyl-6-(4-methoxyphenyl)thieno[2,3-d]pyrimidine-3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 165807-73-8
[6-(4-methoxy-phenyl)-5-methyl-1-(2-nitro-benzyl)-2,4-dioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid ethyl ester

: 165809-18-7
ethyl 2,4(1H,3H)-dioxo-1-(2-aminobenzyl)-5-methyl-6-(4-methoxyphenyl)thieno[2,3-d]pyrimidine-3-acetate

Guidance literature:: With iron; acetic acid; at 80 ℃; for 2h;
DOI:10.1248/cpb.46.1724

Reference yield:

: 122-84-9
4-methoxybenzyl methyl ketone

: 165809-18-7
ethyl 2,4(1H,3H)-dioxo-1-(2-aminobenzyl)-5-methyl-6-(4-methoxyphenyl)thieno[2,3-d]pyrimidine-3-acetate

Guidance literature:: Multi-step reaction with 5 steps

1: NH₄OAc, AcOH / benzene / 24 h / Heating

2: S, Et₂NH / ethanol / 2 h / 60 °C

3: 1.) pyridine, 2.) NaOEt / 1.) 45 deg C, 3 h, 2.) EtOH, RT, 1.5 h

4: 62 percent / K₂CO₃ / dimethylformamide / 15 h / Ambient temperature

5: 80 percent / Fe, AcOH / 2 h / 80 °C

With pyridine; ammonium acetate; sodium ethanolate; iron; potassium carbonate; acetic acid; diethylamine; In ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.46.1724

Reference yield:

: 165809-38-1
2-amino-4-methyl-5-(4-methoxyphenyl)thiophene-3-carboxylic acid ethyl ester

: 165809-18-7
ethyl 2,4(1H,3H)-dioxo-1-(2-aminobenzyl)-5-methyl-6-(4-methoxyphenyl)thieno[2,3-d]pyrimidine-3-acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) pyridine, 2.) NaOEt / 1.) 45 deg C, 3 h, 2.) EtOH, RT, 1.5 h

2: 62 percent / K₂CO₃ / dimethylformamide / 15 h / Ambient temperature

3: 80 percent / Fe, AcOH / 2 h / 80 °C

With pyridine; sodium ethanolate; iron; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.1724