trans-3-<4-<4-(dimethylamino)benzoyl>-1-methyl-1H-pyrrol-2-yl>propenoic acid

Base Information

Chemical Name:trans-3-<4-<4-(dimethylamino)benzoyl>-1-methyl-1H-pyrrol-2-yl>propenoic acid
CAS No.:128843-51-6
Molecular Formula:C₁₇H₁₈N₂O₃
Molecular Weight:298.342
Hs Code.:

Synonyms:trans-3-<4-<4-(dimethylamino)benzoyl>-1-methyl-1H-pyrrol-2-yl>propenoic acid

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Chemical Property of trans-3-<4-<4-(dimethylamino)benzoyl>-1-methyl-1H-pyrrol-2-yl>propenoic acid

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Technology Process of trans-3-<4-<4-(dimethylamino)benzoyl>-1-methyl-1H-pyrrol-2-yl>propenoic acid

There total 4 articles about trans-3-<4-<4-(dimethylamino)benzoyl>-1-methyl-1H-pyrrol-2-yl>propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128843-63-0
4-<4-(dimethylamino)benzoyl>-1-methyl-1H-pyrrole-2-carboxaldehyde

: 128843-51-6
trans-3-<4-<4-(dimethylamino)benzoyl>-1-methyl-1H-pyrrol-2-yl>propenoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / ethanol / 2 h / 70 °C

2: 2N aq. KOH / ethanol / 3 h / 70 °C

With potassium hydroxide; potassium carbonate; In ethanol; 1: Wittig-Horner reaction;
DOI:10.1021/jm021070e

Reference yield:

: 96-54-8
N-Methylpyrrole

: 128843-51-6
trans-3-<4-<4-(dimethylamino)benzoyl>-1-methyl-1H-pyrrol-2-yl>propenoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride / 1,2-dichloro-ethane / 0.25 h / 20 °C

2: AlCl₃ / 1,2-dichloro-ethane / 3 h

3: K₂CO₃ / ethanol / 2 h / 70 °C

4: 2N aq. KOH / ethanol / 3 h / 70 °C

With potassium hydroxide; aluminium trichloride; oxalyl dichloride; potassium carbonate; In ethanol; 1,2-dichloro-ethane; 1: Vilsmeier-Haack reaction / 2: Friedel-Crafts reaction / 3: Wittig-Horner reaction;
DOI:10.1021/jm021070e

Reference yield:

: 1192-58-1
N-methylpyrrole aldehyde

: 128843-51-6
trans-3-<4-<4-(dimethylamino)benzoyl>-1-methyl-1H-pyrrol-2-yl>propenoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: AlCl₃ / 1,2-dichloro-ethane / 3 h

2: K₂CO₃ / ethanol / 2 h / 70 °C

3: 2N aq. KOH / ethanol / 3 h / 70 °C

With potassium hydroxide; aluminium trichloride; potassium carbonate; In ethanol; 1,2-dichloro-ethane; 1: Friedel-Crafts reaction / 2: Wittig-Horner reaction;
DOI:10.1021/jm021070e