C₄₉H₅₇IO₃

Base Information

• Chemical Name: C₄₉H₅₇IO₃
• CAS No.: 1382735-01-4
• Molecular Formula: C₄₉H₅₇IO₃
• Molecular Weight: 820.894
• Mol file: 1382735-01-4.mol

Synonyms:C₄₉H₅₇IO₃

Chemical Property of C₄₉H₅₇IO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₄₉H₅₇IO₃

There total 6 articles about C₄₉H₅₇IO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

boronic acid pinacol ester (1382734-66-8) + 1,4-dihexyl-2,5-diiodobenzene (162715-91-5) → C49H57IO3 (1382735-01-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride; In 1,4-dioxane; water; at 80 ℃;

DOI:10.1002/chem.201201985

Reference yield:

methyl 4-iodosalicylate (18179-39-0) → C49H57IO3 (1382735-01-4)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 80 °C / Inert atmosphere

2: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 16 h / Inert atmosphere; Reflux

3: cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / Reflux

4: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / dimethyl sulfoxide / 15 h / 80 °C

5: cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; potassium carbonate; cesium fluoride; In 1,4-dioxane; water; dimethyl sulfoxide; acetonitrile; 3: |Suzuki-Miyaura Coupling;

DOI:10.1002/chem.201201985

Reference yield:

C31H29IO3 (1382734-60-2) → C49H57IO3 (1382735-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / dimethyl sulfoxide / 15 h / 80 °C

2: cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; cesium fluoride; In 1,4-dioxane; water; dimethyl sulfoxide;

DOI:10.1002/chem.201201985

upstream raw materials:

methyl 4-iodosalicylate

C₃₁H₂₉IO₃

boronic acid pinacol ester

1,4-dihexyl-2,5-diiodobenzene

Downstream raw materials:

C₁₂₂H₁₃₈O₆