(3S,6S)-3-allyl-6-allyloxymethyl-1-(2,4-dimethoxybenzyl)-piperazine-2,5-dione

Base Information

Chemical Name:(3S,6S)-3-allyl-6-allyloxymethyl-1-(2,4-dimethoxybenzyl)-piperazine-2,5-dione
CAS No.:857638-43-8
Molecular Formula:C₂₀H₂₆N₂O₅
Molecular Weight:374.437
Hs Code.:

Synonyms:(3S,6S)-3-allyl-6-allyloxymethyl-1-(2,4-dimethoxybenzyl)-piperazine-2,5-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,6S)-3-allyl-6-allyloxymethyl-1-(2,4-dimethoxybenzyl)-piperazine-2,5-dione

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Technology Process of (3S,6S)-3-allyl-6-allyloxymethyl-1-(2,4-dimethoxybenzyl)-piperazine-2,5-dione

There total 7 articles about (3S,6S)-3-allyl-6-allyloxymethyl-1-(2,4-dimethoxybenzyl)-piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 857638-23-4
(2S,2'S)-3-allyloxy-2-{(2,4-dimethoxybenzyl)-[2'-(9H-fluoren-9-ylmethoxycarbonylamino)-pent-4'-enoyl]-amino}-propionic acid methyl ester

: 857638-43-8
(3S,6S)-3-allyl-6-allyloxymethyl-1-(2,4-dimethoxybenzyl)-piperazine-2,5-dione

Guidance literature:: With piperidine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1039/b416349d

Reference yield:

: 150438-78-1
(2S)-3-allyloxy-2-tert-butoxycarbonylaminopropionic acid

: 857638-43-8
(3S,6S)-3-allyl-6-allyloxymethyl-1-(2,4-dimethoxybenzyl)-piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / methanol; diethyl ether / 0.5 h / 20 °C

2: 93 percent / TFA / CH₂Cl₂ / 0.5 h / 20 °C

3: 85 percent / NaBH(OAc)3 / CH₂Cl₂ / 2 h / 20 °C

4: 53 percent / HATU; 1-hydroxy-7-azabenzotriazole; N-ethylmorpholine / dimethylformamide; CH₂Cl₂ / 20 °C

5: 42 percent / piperidine / CH₂Cl₂ / 2 h / 20 °C

With piperidine; N-ethylmorpholine;; 1-hydroxy-7-aza-benzotriazole; sodium tris(acetoxy)borohydride; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b416349d

Reference yield:

: 107903-44-6
(2S)-3-allyloxy-2-amino-propionic acid

: 857638-43-8
(3S,6S)-3-allyl-6-allyloxymethyl-1-(2,4-dimethoxybenzyl)-piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether; CH₂Cl₂; methanol / 20 °C

2: 85 percent / NaBH(OAc)3 / CH₂Cl₂ / 2 h / 20 °C

3: 53 percent / HATU; 1-hydroxy-7-azabenzotriazole; N-ethylmorpholine / dimethylformamide; CH₂Cl₂ / 20 °C

4: 42 percent / piperidine / CH₂Cl₂ / 2 h / 20 °C

With piperidine; N-ethylmorpholine;; 1-hydroxy-7-aza-benzotriazole; sodium tris(acetoxy)borohydride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b416349d