(4S,5R)-5-(4-Fluoro-3-nitro-phenyl)-2-oxo-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester

Base Information

Chemical Name:(4S,5R)-5-(4-Fluoro-3-nitro-phenyl)-2-oxo-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester
CAS No.:218901-84-9
Molecular Formula:C₁₅H₁₅FN₂O₈
Molecular Weight:370.291
Hs Code.:

Synonyms:(4S,5R)-5-(4-Fluoro-3-nitro-phenyl)-2-oxo-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5R)-5-(4-Fluoro-3-nitro-phenyl)-2-oxo-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester

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Technology Process of (4S,5R)-5-(4-Fluoro-3-nitro-phenyl)-2-oxo-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester

There total 5 articles about (4S,5R)-5-(4-Fluoro-3-nitro-phenyl)-2-oxo-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 218901-84-9
(4S,5R)-5-(4-Fluoro-3-nitro-phenyl)-2-oxo-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Sn(OTf)2, N-ethylpiperidine / 1.) THF, -78 deg C

2: DMAP / CH₂Cl₂

3: HCO₂H, H₂O₂ / H₂O

4: LiOOH / -10 °C

With 1-ethyl-piperidine; dmap; tin(II) trifluoromethanesulfonate; formic acid; lithium hydroperoxide; dihydrogen peroxide; In dichloromethane; water;
DOI:10.1002/(SICI)1521-3773(19981016)37:19<2700::AID-ANIE2700>3.0.CO;2-P

Reference yield:

: 218902-02-4
(4S,5R)-4-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-5-(4-fluoro-3-nitro-phenyl)-2-oxo-oxazolidine-3-carboxylic acid tert-butyl ester

: 218901-84-9
(4S,5R)-5-(4-Fluoro-3-nitro-phenyl)-2-oxo-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester

Guidance literature:: With lithium hydroperoxide; at -10 ℃; Yield given;
DOI:10.1002/(SICI)1521-3773(19981016)37:19<2700::AID-ANIE2700>3.0.CO;2-P

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 218901-84-9
(4S,5R)-5-(4-Fluoro-3-nitro-phenyl)-2-oxo-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DMAP / CH₂Cl₂

2: HCO₂H, H₂O₂ / H₂O

3: LiOOH / -10 °C

With dmap; formic acid; lithium hydroperoxide; dihydrogen peroxide; In dichloromethane; water;
DOI:10.1002/(SICI)1521-3773(19981016)37:19<2700::AID-ANIE2700>3.0.CO;2-P