methyl-6,7-di-<4-(piperidinomethyl)phenyl>-4,9-dimethoxy-3-methyl-thieno-(3,2-g)-quinoxaline-2-carboxylate

Base Information

• Chemical Name: methyl-6,7-di-<4-(piperidinomethyl)phenyl>-4,9-dimethoxy-3-methyl-thieno-(3,2-g)-quinoxaline-2-carboxylate
• CAS No.: 127692-36-8
• Molecular Formula: C₃₉H₄₄N₄O₄S
• Molecular Weight: 664.869
• Mol file: 127692-36-8.mol

Synonyms:methyl-6,7-di-<4-(piperidinomethyl)phenyl>-4,9-dimethoxy-3-methyl-thieno-(3,2-g)-quinoxaline-2-carboxylate

Chemical Property of methyl-6,7-di-<4-(piperidinomethyl)phenyl>-4,9-dimethoxy-3-methyl-thieno-(3,2-g)-quinoxaline-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl-6,7-di-<4-(piperidinomethyl)phenyl>-4,9-dimethoxy-3-methyl-thieno-(3,2-g)-quinoxaline-2-carboxylate

There total 4 articles about methyl-6,7-di-<4-(piperidinomethyl)phenyl>-4,9-dimethoxy-3-methyl-thieno-(3,2-g)-quinoxaline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

piperidine (110-89-4) + methyl-6,7-di-<4-(bromomethyl)phenyl>-4,9-dimethoxy-3-methylthieno<3,2-g>-quinoxalin-2-carboxylate (127714-63-0) → methyl-6,7-di-<4-(piperidinomethyl)phenyl>-4,9-dimethoxy-3-methyl-thieno-(3,2-g)-quinoxaline-2-carboxylate (127692-36-8)

Guidance literature:

In N,N-dimethyl-formamide; for 0.5h; Ambient temperature;

DOI:10.1016/0223-5234(89)90029-9

Reference yield:

α,α'-dibromotolil (21514-58-9) → methyl-6,7-di-<4-(piperidinomethyl)phenyl>-4,9-dimethoxy-3-methyl-thieno-(3,2-g)-quinoxaline-2-carboxylate (127692-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) hydrogen / 1.) Raney nickel / 1.) ethanol, 50 psi, rt.; 2.) acetic acid, 70 deg C, 1 h

2: 68 percent / dimethylformamide / 0.5 h / Ambient temperature

With hydrogen; nickel; In N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(89)90029-9

Reference yield:

methyl 4,7-dimethoxy-3-methylbenzothiophene-2-carboxylate (127692-32-4) → methyl-6,7-di-<4-(piperidinomethyl)phenyl>-4,9-dimethoxy-3-methyl-thieno-(3,2-g)-quinoxaline-2-carboxylate (127692-36-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / conc. nitric acide (70percent) / trifluoroacetic acid / 2 h / 0 °C

2: 1.) hydrogen / 1.) Raney nickel / 1.) ethanol, 50 psi, rt.; 2.) acetic acid, 70 deg C, 1 h

3: 68 percent / dimethylformamide / 0.5 h / Ambient temperature

With hydrogen; nitric acid; nickel; In N,N-dimethyl-formamide; trifluoroacetic acid;

DOI:10.1016/0223-5234(89)90029-9

upstream raw materials:

piperidine

methyl-6,7-di-<4-(bromomethyl)phenyl>-4,9-dimethoxy-3-methylthieno<3,2-g>-quinoxalin-2-carboxylate

α,α'-dibromotolil

methyl 4,7-dimethoxy-3-methylbenzothiophene-2-carboxylate

Downstream raw materials:

6,7-di<4-(piperidinomethyl)phenyl>-4,9-dimethoxy-3-methylthieno(3,2-g)-quinoxaline-2-carboxylic acid