N-{3-[(6-aminopyridin-3-yl)oxy]-4-methylphenyl}-3-(1-cyano-1-methylethyl)benzamide

Base Information

Chemical Name:N-{3-[(6-aminopyridin-3-yl)oxy]-4-methylphenyl}-3-(1-cyano-1-methylethyl)benzamide
CAS No.:1092395-10-2
Molecular Formula:C₂₃H₂₂N₄O₂
Molecular Weight:386.453
Hs Code.:

Synonyms:N-{3-[(6-aminopyridin-3-yl)oxy]-4-methylphenyl}-3-(1-cyano-1-methylethyl)benzamide

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Chemical Property of N-{3-[(6-aminopyridin-3-yl)oxy]-4-methylphenyl}-3-(1-cyano-1-methylethyl)benzamide

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Technology Process of N-{3-[(6-aminopyridin-3-yl)oxy]-4-methylphenyl}-3-(1-cyano-1-methylethyl)benzamide

There total 4 articles about N-{3-[(6-aminopyridin-3-yl)oxy]-4-methylphenyl}-3-(1-cyano-1-methylethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1092395-09-9
3-(1-cyano-1-methylethyl)-N-{4-methyl-3-[(6-nitropyridin-3-yl)oxy]phenyl}benzamide

: 1092395-10-2
N-{3-[(6-aminopyridin-3-yl)oxy]-4-methylphenyl}-3-(1-cyano-1-methylethyl)benzamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 16h; under 1520.1 Torr;

Reference yield:

: 1092395-14-6
3-(1-cyanocyclopropyl)benzoyl chloride

: 1092395-10-2
N-{3-[(6-aminopyridin-3-yl)oxy]-4-methylphenyl}-3-(1-cyano-1-methylethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / tetrahydrofuran; water / 5 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C / 1520.1 Torr

With hydrogen; sodium hydrogencarbonate; caesium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1092395-08-8
3-(1-cyano-1-methylethyl)-N-(3-hydroxy-4-methylphenyl)benzamide

: 1092395-10-2
N-{3-[(6-aminopyridin-3-yl)oxy]-4-methylphenyl}-3-(1-cyano-1-methylethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C / 1520.1 Torr

With hydrogen; caesium carbonate; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;