1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(4-methyl-3-((2-oxoindolin-6-yl)amino)phenyl)urea

Base Information

Chemical Name:1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(4-methyl-3-((2-oxoindolin-6-yl)amino)phenyl)urea
CAS No.:1353644-07-1
Molecular Formula:C₂₃H₁₈F₄N₄O₂
Molecular Weight:458.415
Hs Code.:

Synonyms:1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(4-methyl-3-((2-oxoindolin-6-yl)amino)phenyl)urea

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Chemical Property of 1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(4-methyl-3-((2-oxoindolin-6-yl)amino)phenyl)urea

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Technology Process of 1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(4-methyl-3-((2-oxoindolin-6-yl)amino)phenyl)urea

There total 6 articles about 1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(4-methyl-3-((2-oxoindolin-6-yl)amino)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1353644-06-0
6-((5-amino-2-methylphenyl)amino)indolin-2-one

: 69922-27-6
1-fluoro-2-isocyanato-4-(trifluoromethyl)benzene

: 1353644-07-1
1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(4-methyl-3-((2-oxoindolin-6-yl)amino)phenyl)urea

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/ml200261d

Reference yield:

: dimethyl 2-(4-bromo-2-nitrophenyl)malonate

: 1353644-07-1
1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(4-methyl-3-((2-oxoindolin-6-yl)amino)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / water; acetic acid / 110 °C

2: sulfuric acid / 80 °C

3: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 110 °C

4: palladium 10% on activated carbon; hydrogen / acetic acid / 20 °C

5: triethylamine / tetrahydrofuran / 20 °C

With hydrogenchloride; sulfuric acid; palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; triethylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; water; acetic acid;
DOI:10.1021/ml200261d

Reference yield:

: 199328-35-3
ethyl 2-(4-bromo-2-nitrophenyl)acetate

: 1353644-07-1
1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(4-methyl-3-((2-oxoindolin-6-yl)amino)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 110 °C

2: palladium 10% on activated carbon; hydrogen / acetic acid / 20 °C

3: triethylamine / tetrahydrofuran / 20 °C

With palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; acetic acid;
DOI:10.1021/ml200261d