<3aS-(3aα,4β,6aα)>-2-(dimethylamino)ethyl 4-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>butylamino> benzoate

Base Information

• Chemical Name: <3aS-(3aα,4β,6aα)>-2-(dimethylamino)ethyl 4-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>butylamino> benzoate
• CAS No.: 108060-67-9
• Molecular Formula: C₂₅H₃₈N₄O₄S
• Molecular Weight: 490.667
• Mol file: 108060-67-9.mol

Synonyms:<3aS-(3aα,4β,6aα)>-2-(dimethylamino)ethyl 4-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>butylamino> benzoate

Chemical Property of <3aS-(3aα,4β,6aα)>-2-(dimethylamino)ethyl 4-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>butylamino> benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <3aS-(3aα,4β,6aα)>-2-(dimethylamino)ethyl 4-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>butylamino> benzoate

There total 2 articles about <3aS-(3aα,4β,6aα)>-2-(dimethylamino)ethyl 4-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>butylamino> benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

amethocaine (94-24-6) + biotinyl chloride → <3aS-(3aα,4β,6aα)>-2-(dimethylamino)ethyl 4-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>butylamino> benzoate (108060-67-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 2h;

DOI:10.1021/jm00391a006

Reference yield:

5-((3aS,4R,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid (58-85-5,22879-79-4) → <3aS-(3aα,4β,6aα)>-2-(dimethylamino)ethyl 4-<<5-(hexahydro-2-oxo-1H-thieno<3,4-d>imidazol-4-yl)-1-oxopentyl>butylamino> benzoate (108060-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 0.25 h / Ambient temperature

2: 68 percent / triethylamine / dimethylformamide / 2 h / 0 - 25 °C

With thionyl chloride; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00391a006

upstream raw materials:

amethocaine

5-((3aS,4R,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid