Technology Process of (E)-6-(4-fluorobenzylidene)-1,8,8-trimethyloctahydropyrrolo[1,2-a]pyrimidine
There total 3 articles about (E)-6-(4-fluorobenzylidene)-1,8,8-trimethyloctahydropyrrolo[1,2-a]pyrimidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-(4-fluorophenyl)-2,2-dimethylpent-4-ynal; N-Methyl-1,3-propanediamine;
In
dimethyl sulfoxide;
at 20 ℃;
With
potassium hydroxide;
In
dimethyl sulfoxide;
at 20 ℃;
stereoselective reaction;
DOI:10.1016/j.mencom.2013.05.006
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: phasetransfer catalyst
2.1: dimethyl sulfoxide / 20 °C
2.2: 20 °C
With
phasetransfer catalyst;
In
dimethyl sulfoxide;
DOI:10.1016/j.mencom.2013.05.006
- Guidance literature:
-
Multi-step reaction with 3 steps
1: thionyl chloride; triethylamine / tetrachloromethane
2: sodium hydroxide; sodium iodide; tetra-(n-butyl)ammonium iodide / water; toluene / 50 °C
3: potassium hydroxide / dimethyl sulfoxide / 15 h / 20 °C
With
thionyl chloride; tetra-(n-butyl)ammonium iodide; triethylamine; sodium iodide; potassium hydroxide; sodium hydroxide;
In
tetrachloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1007/s11172-013-0351-3
