tert-butyl 2-(3-fluoro-4-(methoxycarbonyl)phenyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 2-(3-fluoro-4-(methoxycarbonyl)phenyl)pyrrolidine-1-carboxylate
• CAS No.: 934162-68-2
• Molecular Formula: C₁₇H₂₂FNO₄
• Molecular Weight: 323.364

Synonyms:tert-butyl 2-(3-fluoro-4-(methoxycarbonyl)phenyl)pyrrolidine-1-carboxylate

Chemical Property of tert-butyl 2-(3-fluoro-4-(methoxycarbonyl)phenyl)pyrrolidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 2-(3-fluoro-4-(methoxycarbonyl)phenyl)pyrrolidine-1-carboxylate

There total 1 articles about tert-butyl 2-(3-fluoro-4-(methoxycarbonyl)phenyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyl 2-(3-fluoro-4-methoxycarbonyl)phenyl-1H-pyrrole-1-carboxylate (1128075-31-9) → tert-butyl 2-(3-fluoro-4-(methoxycarbonyl)phenyl)pyrrolidine-1-carboxylate (934162-68-2)

Guidance literature:

With platinum on carbon; hydrogen; In acetic acid; for 12h; under 3102.97 Torr;

DOI:10.1021/jm901775y

Reference yield:

tert-butyl 2-(3-fluoro-4-(methoxycarbonyl)phenyl)pyrrolidine-1-carboxylate (934162-68-2) → tert-butyl 2-(4-carboxy-3-fluorophenyl)pyrrolidine-1-carboxylate (1187931-34-5)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

DOI:10.1021/jm901775y

Reference yield:

tert-butyl 2-(3-fluoro-4-(methoxycarbonyl)phenyl)pyrrolidine-1-carboxylate (934162-68-2) → (R)-tert-butyl 2-(3-fluoro-4-(methoxycarbonyl)phenyl)pyrrolidine-1-carboxylate (934162-58-0) + (S)-tert-butyl 2-(3-fluoro-4-(methoxycarbonyl)phenyl)pyrrolidine-1-carboxylate (934162-62-6)

Guidance literature:

With Chiral HPLC, Whelk O column; optical yield given as %ee; Resolution of racemate;

DOI:10.1021/jm901775y

upstream raw materials:

tert-butyl 2-(3-fluoro-4-methoxycarbonyl)phenyl-1H-pyrrole-1-carboxylate

Downstream raw materials:

tert-butyl 2-(4-carboxy-3-fluorophenyl)pyrrolidine-1-carboxylate

(R)-tert-butyl 2-(3-fluoro-4-(methoxycarbonyl)phenyl)pyrrolidine-1-carboxylate

(S)-tert-butyl 2-(3-fluoro-4-(methoxycarbonyl)phenyl)pyrrolidine-1-carboxylate

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