2-[3,5-bis-benzyloxy-2-(3-methyl-but-2-enyl)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

Base Information

Chemical Name:2-[3,5-bis-benzyloxy-2-(3-methyl-but-2-enyl)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole
CAS No.:737800-05-4
Molecular Formula:C₃₀H₃₃NO₃
Molecular Weight:455.597
Hs Code.:

Synonyms:2-[3,5-bis-benzyloxy-2-(3-methyl-but-2-enyl)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

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Chemical Property of 2-[3,5-bis-benzyloxy-2-(3-methyl-but-2-enyl)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

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Technology Process of 2-[3,5-bis-benzyloxy-2-(3-methyl-but-2-enyl)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

There total 1 articles about 2-[3,5-bis-benzyloxy-2-(3-methyl-but-2-enyl)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 111536-51-7
2-(3,5-dibenzyloxyphenyl)-4,5-dihydro-4,4-dimethyloxazole

: 870-63-3
prenyl bromide

: 737800-05-4
2-[3,5-bis-benzyloxy-2-(3-methyl-but-2-enyl)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: 2-(3,5-dibenzyloxyphenyl)-4,5-dihydro-4,4-dimethyloxazole; With n-butyllithium; at -78 ℃;

prenyl bromide; In 1,2-dimethoxyethane; at 0 ℃; Further stages.;
DOI:10.1016/j.tetlet.2004.05.063

Reference yield: 62.0%

: 79-22-1
methyl chloroformate

: 737800-05-4
2-[3,5-bis-benzyloxy-2-(3-methyl-but-2-enyl)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

: 737800-06-5
4,6-bis-benzyloxy-2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-3-(3-methyl-but-2-enyl)-benzoic acid methyl ester

Guidance literature:: 2-[3,5-bis-benzyloxy-2-(3-methyl-but-2-enyl)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole; With n-butyllithium; at -78 ℃;

methyl chloroformate; In 1,2-dimethoxyethane; at 0 ℃; Further stages.;
DOI:10.1016/j.tetlet.2004.05.063

Reference yield:

: 737800-05-4
2-[3,5-bis-benzyloxy-2-(3-methyl-but-2-enyl)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

: pestalone

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-BuLi / -78 °C

1.2: 62 percent / 1,2-dimethoxy-ethane / 0 °C

2.1: 86 percent / LiAlH₄ / tetrahydrofuran

3.1: 99 percent / imidazole / dimethylformamide

4.1: MeI / 40 °C

4.2: NaBH₄ / methanol; tetrahydrofuran

4.3: 69 percent / aq. AcOH / tetrahydrofuran

5.1: 99 percent / n-BuLi / tetrahydrofuran / -78 - 0 °C

6.1: 100 percent / TBAF / tetrahydrofuran

7.1: 53 percent / IBX; DMSO / toluene

8.1: 100 percent / aq. HCl / tetrahydrofuran

9.1: 100 percent / K₂CO₃ / acetone / 40 °C

10.1: 56 percent / BBr₃ / CH₂Cl₂ / -78 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; tetrabutyl ammonium fluoride; boron tribromide; potassium carbonate; dimethyl sulfoxide; methyl iodide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/j.tetlet.2004.05.063