6-Butyl-2-methyl-3-thiophen-2-ylmethyl-5-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-pyrimidin-4-one

Base Information

• Chemical Name: 6-Butyl-2-methyl-3-thiophen-2-ylmethyl-5-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-pyrimidin-4-one
• CAS No.: 172292-51-2
• Molecular Formula: C₄₇H₄₂N₆OS
• Molecular Weight: 738.956

Synonyms:6-Butyl-2-methyl-3-thiophen-2-ylmethyl-5-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-pyrimidin-4-one

Chemical Property of 6-Butyl-2-methyl-3-thiophen-2-ylmethyl-5-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-pyrimidin-4-one

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 6-Butyl-2-methyl-3-thiophen-2-ylmethyl-5-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-pyrimidin-4-one

There total 4 articles about 6-Butyl-2-methyl-3-thiophen-2-ylmethyl-5-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-thenyl bromide (45438-73-1) + 6-butyl-2-methyl-5-<<2'-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-yl>methyl>pyrimidin-4(1H)-one (148564-13-0) → 6-Butyl-2-methyl-3-thiophen-2-ylmethyl-5-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-pyrimidin-4-one (172292-51-2)

Guidance literature:

With sodium hydride; lithium bromide; Yield given. Multistep reaction;

DOI:10.1021/jm00024a008

Reference yield:

methyl 3-oxoheptanoate (39815-78-6) → 6-Butyl-2-methyl-3-thiophen-2-ylmethyl-5-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-pyrimidin-4-one (172292-51-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / NaH / tetrahydrofuran / 10 h

2: 70 percent / CH₃ONa / methanol; dioxane / 20 h / Ambient temperature

3: 1.) NaH, 2.) LiBr

With sodium methylate; sodium hydride; lithium bromide; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1021/jm00024a008

Reference yield:

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole (124750-51-2) → 6-Butyl-2-methyl-3-thiophen-2-ylmethyl-5-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-pyrimidin-4-one (172292-51-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / NaH / tetrahydrofuran / 10 h

2: 70 percent / CH₃ONa / methanol; dioxane / 20 h / Ambient temperature

3: 1.) NaH, 2.) LiBr

With sodium methylate; sodium hydride; lithium bromide; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1021/jm00024a008

upstream raw materials:

2-thenyl bromide

6-butyl-2-methyl-5-<<2'-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-yl>methyl>pyrimidin-4(1H)-one

methyl 3-oxoheptanoate

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

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