5-{[2-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]amino}-7-(4-hydroxypiperidin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one

Base Information

Chemical Name:5-{[2-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]amino}-7-(4-hydroxypiperidin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one
CAS No.:1390656-16-2
Molecular Formula:C₂₃H₂₇ClN₆O₂
Molecular Weight:454.959
Hs Code.:

Synonyms:5-{[2-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]amino}-7-(4-hydroxypiperidin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one

Suppliers and Price of 5-{[2-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]amino}-7-(4-hydroxypiperidin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-{[2-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]amino}-7-(4-hydroxypiperidin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-{[2-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]amino}-7-(4-hydroxypiperidin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one

There total 12 articles about 5-{[2-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]amino}-7-(4-hydroxypiperidin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1390656-16-2
5-{[2-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]amino}-7-(4-hydroxypiperidin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: thionyl chloride / 5 h / 20 °C / Cooling with ice

2.1: sodium tris(acetoxy)borohydride / ethanol / 3 h / 80 °C

3.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

4.1: toluene-4-sulfonic acid / toluene; methanol / 2 h / Reflux

5.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C

5.2: 2 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: 1,4-dioxane / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

9.1: toluene-4-sulfonic acid / butan-1-ol / 130 °C

10.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 120 °C / Sealed tube

With n-butyllithium; thionyl chloride; sodium tris(acetoxy)borohydride; Dess-Martin periodane; toluene-4-sulfonic acid; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; toluene; butan-1-ol;

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1390657-73-4
7-chloro-5-(2-chloro-4-(pyrrolidin-1-ylmethyl)phenylamino)pyrido[3,4-d]pyridazin-4(3H)-one

: 1390656-16-2
5-{[2-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]amino}-7-(4-hydroxypiperidin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 120 ℃; Sealed tube;

Reference yield:

: 1604-14-4
2,6-dichloroisonicotinic acid ethyl ester

: 1390656-16-2
5-{[2-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]amino}-7-(4-hydroxypiperidin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium tris(acetoxy)borohydride / ethanol / 3 h / 80 °C

2.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

3.1: toluene-4-sulfonic acid / toluene; methanol / 2 h / Reflux

4.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C

4.2: 2 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 20 °C

6.1: 1,4-dioxane / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

8.1: toluene-4-sulfonic acid / butan-1-ol / 130 °C

9.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 120 °C / Sealed tube

With n-butyllithium; sodium tris(acetoxy)borohydride; Dess-Martin periodane; toluene-4-sulfonic acid; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; toluene; butan-1-ol;