1,1-dimethylethyl R-<<<1S-methyl-2-oxo-2-(phenylmethoxy)ethyl>amino>carbonyl> benzenebutanoate

Base Information

Chemical Name:1,1-dimethylethyl R-<<<1S-methyl-2-oxo-2-(phenylmethoxy)ethyl>amino>carbonyl> benzenebutanoate
CAS No.:141215-90-9
Molecular Formula:C₂₅H₃₁NO₅
Molecular Weight:425.525
Hs Code.:

Synonyms:1,1-dimethylethyl R-<<<1S-methyl-2-oxo-2-(phenylmethoxy)ethyl>amino>carbonyl> benzenebutanoate

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Chemical Property of 1,1-dimethylethyl R-<<<1S-methyl-2-oxo-2-(phenylmethoxy)ethyl>amino>carbonyl> benzenebutanoate

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Technology Process of 1,1-dimethylethyl R-<<<1S-methyl-2-oxo-2-(phenylmethoxy)ethyl>amino>carbonyl> benzenebutanoate

There total 4 articles about 1,1-dimethylethyl R-<<<1S-methyl-2-oxo-2-(phenylmethoxy)ethyl>amino>carbonyl> benzenebutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 5557-81-3,5557-83-5,34404-37-0
L-alanine benzyl ester hydrochloride

: 122225-33-6
(2R)-3-tert-Butyloxycarbonyl-2-phenylmethylpropionic Acid

: 141215-90-9
1,1-dimethylethyl R-<<<1S-methyl-2-oxo-2-(phenylmethoxy)ethyl>amino>carbonyl> benzenebutanoate

Guidance literature:: With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform; at 0 ℃; for 1h;
DOI:10.1080/00397919208020851

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 141215-90-9
1,1-dimethylethyl R-<<<1S-methyl-2-oxo-2-(phenylmethoxy)ethyl>amino>carbonyl> benzenebutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaN(TMS)2, 2.) HMPA, n-Bu₄NI / 1.) THF, -70 deg C, 1 h, 2.) THF, -70 deg C, 10 h

2: 83 percent / LiOH, 30percent aq. H₂O₂ / tetrahydrofuran / 4 h / Ambient temperature

3: 87 percent / N-methylmorpholine, 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / 1 h / 0 °C

With 4-methyl-morpholine; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; dihydrogen peroxide; sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform;
DOI:10.1080/00397919208020851

Reference yield:

: bornane sultam

: 141215-90-9
1,1-dimethylethyl R-<<<1S-methyl-2-oxo-2-(phenylmethoxy)ethyl>amino>carbonyl> benzenebutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaN(TMS)2, 2.) HMPA, n-Bu₄NI / 1.) THF, -70 deg C, 1 h, 2.) THF, -70 deg C, 10 h

2: 83 percent / LiOH, 30percent aq. H₂O₂ / tetrahydrofuran / 4 h / Ambient temperature

3: 87 percent / N-methylmorpholine, 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / 1 h / 0 °C

With 4-methyl-morpholine; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; dihydrogen peroxide; sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform;
DOI:10.1080/00397919208020851