3-(2-bromo-phenyl)-4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-1H-pyrrole-2-carboxylic acid phenylamide

Base Information

Chemical Name:3-(2-bromo-phenyl)-4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-1H-pyrrole-2-carboxylic acid phenylamide
CAS No.:889878-48-2
Molecular Formula:C₂₇H₂₂BrFN₂O₂
Molecular Weight:505.386
Hs Code.:

Synonyms:3-(2-bromo-phenyl)-4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-1H-pyrrole-2-carboxylic acid phenylamide

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Chemical Property of 3-(2-bromo-phenyl)-4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-1H-pyrrole-2-carboxylic acid phenylamide

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Technology Process of 3-(2-bromo-phenyl)-4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-1H-pyrrole-2-carboxylic acid phenylamide

There total 10 articles about 3-(2-bromo-phenyl)-4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-1H-pyrrole-2-carboxylic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₁₆BrClFNO₂

: 62-53-3
aniline

: 889878-48-2
3-(2-bromo-phenyl)-4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-1H-pyrrole-2-carboxylic acid phenylamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 25 ℃; for 12h;
DOI:10.1016/j.bmcl.2007.05.097

Reference yield:

: 889878-44-8
3-(2-bromo-phenyl)-4-(4-fluoro-phenyl)-1H-pyrrole-2-carboxylic acid ethyl ester

: 889878-48-2
3-(2-bromo-phenyl)-4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-1H-pyrrole-2-carboxylic acid phenylamide

Guidance literature:: Multi-step reaction with 5 steps

1: KOH / dimethylsulfoxide / 2 h / 25 °C

2: POCl₃ / 1,2-dichloro-ethane / 18 h / 80 °C

3: NaOH / methanol / 3 h / 60 °C

4: SOCl₂ / 1 h / 70 °C

5: Et₃N / CH₂Cl₂ / 12 h / 0 - 25 °C

With potassium hydroxide; sodium hydroxide; thionyl chloride; triethylamine; trichlorophosphate; In methanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; 2: Vilsmeier-Haack formylation;
DOI:10.1016/j.bmcl.2007.05.097

Reference yield:

: 889878-45-9
3-(2-bromo-phenyl)-4-(4-fluoro-phenyl)-1-isopropyl-1H-pyrrole-2-carboxylic acid ethyl ester

: 889878-48-2
3-(2-bromo-phenyl)-4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-1H-pyrrole-2-carboxylic acid phenylamide

Guidance literature:: Multi-step reaction with 4 steps

1: POCl₃ / 1,2-dichloro-ethane / 18 h / 80 °C

2: NaOH / methanol / 3 h / 60 °C

3: SOCl₂ / 1 h / 70 °C

4: Et₃N / CH₂Cl₂ / 12 h / 0 - 25 °C

With sodium hydroxide; thionyl chloride; triethylamine; trichlorophosphate; In methanol; dichloromethane; 1,2-dichloro-ethane; 1: Vilsmeier-Haack formylation;
DOI:10.1016/j.bmcl.2007.05.097