(Z)-3-{2-[(S)-3-[4-(6-tert-Butoxycarbonylamino-hexyloxy)-phenyl]-2-(3-phenyl-propionylamino)-propionyloxy]-phenyl}-acrylic acid

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Chemical Name:(Z)-3-{2-[(S)-3-[4-(6-tert-Butoxycarbonylamino-hexyloxy)-phenyl]-2-(3-phenyl-propionylamino)-propionyloxy]-phenyl}-acrylic acid
CAS No.:220910-37-2
Molecular Formula:C₃₈H₄₆N₂O₈
Molecular Weight:658.792
Hs Code.:

Synonyms:(Z)-3-{2-[(S)-3-[4-(6-tert-Butoxycarbonylamino-hexyloxy)-phenyl]-2-(3-phenyl-propionylamino)-propionyloxy]-phenyl}-acrylic acid

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Chemical Property of (Z)-3-{2-[(S)-3-[4-(6-tert-Butoxycarbonylamino-hexyloxy)-phenyl]-2-(3-phenyl-propionylamino)-propionyloxy]-phenyl}-acrylic acid

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Technology Process of (Z)-3-{2-[(S)-3-[4-(6-tert-Butoxycarbonylamino-hexyloxy)-phenyl]-2-(3-phenyl-propionylamino)-propionyloxy]-phenyl}-acrylic acid

There total 5 articles about (Z)-3-{2-[(S)-3-[4-(6-tert-Butoxycarbonylamino-hexyloxy)-phenyl]-2-(3-phenyl-propionylamino)-propionyloxy]-phenyl}-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 220910-35-0
(S)-3-[4-(6-tert-Butoxycarbonylamino-hexyloxy)-phenyl]-2-(3-phenyl-propionylamino)-propionic acid 2-((Z)-3-oxo-propenyl)-phenyl ester

: 220910-37-2
(Z)-3-{2-[(S)-3-[4-(6-tert-Butoxycarbonylamino-hexyloxy)-phenyl]-2-(3-phenyl-propionylamino)-propionyloxy]-phenyl}-acrylic acid

Guidance literature:: With sodium dihydrogenphosphate; dihydrogen peroxide; In water; at 10 ℃; for 3h;
DOI:10.1248/cpb.47.90

Reference yield:

: 142355-89-3
(S)-3-[4-(6-tert-Butoxycarbonylamino-hexyloxy)-phenyl]-2-(3-phenyl-propionylamino)-propionic acid

: 220910-37-2
(Z)-3-{2-[(S)-3-[4-(6-tert-Butoxycarbonylamino-hexyloxy)-phenyl]-2-(3-phenyl-propionylamino)-propionyloxy]-phenyl}-acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / DCC, DMAP / tetrahydrofuran / 6.5 h / 0 - 20 °C

2: 96 percent / aq. HOAc / tetrahydrofuran / 7 h / Ambient temperature

3: 82 percent / MnO₂ / CH₂Cl₂ / 31 h / Ambient temperature

4: 67 percent / NaH₂PO₄, H₂O₂ / H₂O / 3 h / 10 °C

With dmap; manganese(IV) oxide; sodium dihydrogenphosphate; dihydrogen peroxide; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1248/cpb.47.90

Reference yield:

: 185995-96-4
(Z)-2-(3-(tert-butyldimethylsilyloxy)propenyl)phenol

: 220910-37-2
(Z)-3-{2-[(S)-3-[4-(6-tert-Butoxycarbonylamino-hexyloxy)-phenyl]-2-(3-phenyl-propionylamino)-propionyloxy]-phenyl}-acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / DCC, DMAP / tetrahydrofuran / 6.5 h / 0 - 20 °C

2: 96 percent / aq. HOAc / tetrahydrofuran / 7 h / Ambient temperature

3: 82 percent / MnO₂ / CH₂Cl₂ / 31 h / Ambient temperature

4: 67 percent / NaH₂PO₄, H₂O₂ / H₂O / 3 h / 10 °C

With dmap; manganese(IV) oxide; sodium dihydrogenphosphate; dihydrogen peroxide; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1248/cpb.47.90