Technology Process of (4R,6S)-4-(2-Benzenesulfonyl-ethyl)-2,2-dimethyl-6-pent-4-enyl-[1,3]dioxane
There total 8 articles about (4R,6S)-4-(2-Benzenesulfonyl-ethyl)-2,2-dimethyl-6-pent-4-enyl-[1,3]dioxane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methylphenylsulfonate;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -30 - 20 ℃;
Toluene-4-sulfonic acid (4R,6S)-2,2-dimethyl-6-pent-4-enyl-[1,3]dioxan-4-ylmethyl ester;
In
tetrahydrofuran; hexane;
for 22h;
Heating;
DOI:10.1016/S0040-4020(02)00056-X
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-BuLi / tetrahydrofuran; hexane / -20 °C
1.2: 80 percent / tetrahydrofuran; hexane / 5 h / -78 - 20 °C
2.1: 86 percent / CuCl2; CuO; H2O / acetone / 1 h / 20 °C
3.1: 88 percent / Me4NHB(OAc)3 / acetonitrile; acetic acid / 20 h / -30 °C
4.1: 100 percent / D-10-camphorsulfonic acid / acetone / 48 h / 20 °C
5.1: 99 percent / Na; liquid NH3 / tetrahydrofuran / 0.5 h / -78 °C
6.1: 80.5 mg / pyridine / 3.5 h / 0 °C
7.1: n-BuLi / tetrahydrofuran; hexane / -30 - 20 °C
7.2: 86 percent / tetrahydrofuran; hexane / 22 h / Heating
With
pyridine; n-butyllithium; camphor-10-sulfonic acid; ammonia; water; sodium; copper(II) oxide; copper dichloride; tetramethylammonium triacetoxyborohydride;
In
tetrahydrofuran; hexane; acetic acid; acetone; acetonitrile;
DOI:10.1016/S0040-4020(02)00056-X
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -20 °C
1.2: 98 percent / tetrahydrofuran; hexane / 3 h / -78 - 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / -20 °C
2.2: 80 percent / tetrahydrofuran; hexane / 5 h / -78 - 20 °C
3.1: 86 percent / CuCl2; CuO; H2O / acetone / 1 h / 20 °C
4.1: 88 percent / Me4NHB(OAc)3 / acetonitrile; acetic acid / 20 h / -30 °C
5.1: 100 percent / D-10-camphorsulfonic acid / acetone / 48 h / 20 °C
6.1: 99 percent / Na; liquid NH3 / tetrahydrofuran / 0.5 h / -78 °C
7.1: 80.5 mg / pyridine / 3.5 h / 0 °C
8.1: n-BuLi / tetrahydrofuran; hexane / -30 - 20 °C
8.2: 86 percent / tetrahydrofuran; hexane / 22 h / Heating
With
pyridine; n-butyllithium; camphor-10-sulfonic acid; ammonia; water; sodium; copper(II) oxide; copper dichloride; tetramethylammonium triacetoxyborohydride;
In
tetrahydrofuran; hexane; acetic acid; acetone; acetonitrile;
DOI:10.1016/S0040-4020(02)00056-X
