4-(4-trifluoromethylbenzenesulfonyl)-3,4-dihydro-2H-[1,4]oxazine

Base Information

Chemical Name:4-(4-trifluoromethylbenzenesulfonyl)-3,4-dihydro-2H-[1,4]oxazine
CAS No.:1610528-75-0
Molecular Formula:C₁₁H₁₀F₃NO₃S
Molecular Weight:293.267
Hs Code.:

Synonyms:4-(4-trifluoromethylbenzenesulfonyl)-3,4-dihydro-2H-[1,4]oxazine

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Chemical Property of 4-(4-trifluoromethylbenzenesulfonyl)-3,4-dihydro-2H-[1,4]oxazine

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Technology Process of 4-(4-trifluoromethylbenzenesulfonyl)-3,4-dihydro-2H-[1,4]oxazine

There total 3 articles about 4-(4-trifluoromethylbenzenesulfonyl)-3,4-dihydro-2H-[1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1610527-82-6
4-(2-bromo-4-trifluoromethylbenzenesulfonyl)morpholine

: 1610528-75-0
4-(4-trifluoromethylbenzenesulfonyl)-3,4-dihydro-2H-[1,4]oxazine

Guidance literature:: With palladium diacetate; potassium pivalate; In N,N-dimethyl acetamide; at 150 ℃; for 16h; Schlenk technique; Inert atmosphere;
DOI:10.1002/adsc.201300795

Reference yield:

: 54403-98-4
2-bromo-4-(trifluoromethyl)benzene-1-sulfonyl chloride

: 1610528-75-0
4-(4-trifluoromethylbenzenesulfonyl)-3,4-dihydro-2H-[1,4]oxazine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

2: potassium pivalate; palladium diacetate / N,N-dimethyl acetamide / 16 h / 150 °C / Schlenk technique; Inert atmosphere

With palladium diacetate; potassium pivalate; triethylamine; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1002/adsc.201300795

Reference yield:

: 401-78-5
3-bromo-1-trifluoromethylbenzene

: 1610528-75-0
4-(4-trifluoromethylbenzenesulfonyl)-3,4-dihydro-2H-[1,4]oxazine

Guidance literature:: Multi-step reaction with 3 steps

1: chlorosulfonic acid / Schlenk technique; Inert atmosphere

2: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

3: potassium pivalate; palladium diacetate / N,N-dimethyl acetamide / 16 h / 150 °C / Schlenk technique; Inert atmosphere

With chlorosulfonic acid; palladium diacetate; potassium pivalate; triethylamine; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1002/adsc.201300795