3-tert-butoxyazetidine-1-carboxylic acid 2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]benzylamide

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Chemical Name:3-tert-butoxyazetidine-1-carboxylic acid 2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]benzylamide
CAS No.:1607005-45-7
Molecular Formula:C₂₅H₂₈FN₇O₂
Molecular Weight:477.541
Hs Code.:

Synonyms:3-tert-butoxyazetidine-1-carboxylic acid 2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]benzylamide

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Chemical Property of 3-tert-butoxyazetidine-1-carboxylic acid 2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]benzylamide

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Technology Process of 3-tert-butoxyazetidine-1-carboxylic acid 2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]benzylamide

There total 3 articles about 3-tert-butoxyazetidine-1-carboxylic acid 2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1147530-63-9
3-(tert-butoxy)azetidine

: C₁₇H₁₅FN₆

: 530-62-1
1,1'-carbonyldiimidazole

: 1607005-45-7
3-tert-butoxyazetidine-1-carboxylic acid 2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]benzylamide

Guidance literature:: C₁₇H₁₅FN₆; 1,1'-carbonyldiimidazole; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

3-(tert-butoxy)azetidine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1607005-67-3
{2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]benzyl}carbamic acid tert-butyl ester

: 1607005-45-7
3-tert-butoxyazetidine-1-carboxylic acid 2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1607005-66-2
{4-[6-bromo-7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2-fluorobenzyl}carbamic acid tert-butyl ester

: 1607005-45-7
3-tert-butoxyazetidine-1-carboxylic acid 2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 1 h / 160 °C / Microwave irradiation; Sealed tube

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;