(2,4-diethyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate

Base Information

Chemical Name:(2,4-diethyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate
CAS No.:1600565-07-8
Molecular Formula:C₂HF₃O₂*C₂₉H₂₈N₄O
Molecular Weight:562.591
Hs Code.:

Synonyms:(2,4-diethyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate

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Chemical Property of (2,4-diethyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate

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Technology Process of (2,4-diethyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate

There total 11 articles about (2,4-diethyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1600563-62-9
(2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(pyridin-4-yl)methanol

: 557-20-0
diethylzinc

: 76-05-1
trifluoroacetic acid

: 1600565-07-8
(2,4-diethyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate

Guidance literature:: (2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(pyridin-4-yl)methanol; diethylzinc; With 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; In tetrahydrofuran; n-heptane; at 66 ℃; for 22h; Sealed tube; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; n-heptane; Sealed tube; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile; Sealed tube; Inert atmosphere;

Reference yield:

: 1600562-94-4
(1-methyl-1H-imidazol-5-yl)(pyridin-4-yl)methanone

: 1600565-07-8
(2,4-diethyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.17 h / -78 °C / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate / tetrahydrofuran; n-heptane / 22 h / 66 °C / Sealed tube; Inert atmosphere

2.2: Sealed tube; Inert atmosphere

2.3: Sealed tube; Inert atmosphere

With n-butyllithium; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; In tetrahydrofuran; hexane; n-heptane;

Reference yield:

: 452349-62-1
methyl 5-bromo-2-(2-phenylacetamido)benzoate

: 1600565-07-8
(2,4-diethyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane; water / 4 h / -78 - 20 °C

2.1: trichlorophosphate / 3.5 h / 107 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.17 h / -78 °C / Inert atmosphere

3.3: 20 °C / Inert atmosphere

4.1: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate / tetrahydrofuran; n-heptane / 22 h / 66 °C / Sealed tube; Inert atmosphere

4.2: Sealed tube; Inert atmosphere

4.3: Sealed tube; Inert atmosphere

With n-butyllithium; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; hexane; n-heptane; water;