4-{3-[4-(4-n-heptylbenzyloxy)phenyl]-1,2,4-oxadiazol-5-yl}phenyl 4-hexylbenzoate

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Chemical Name:4-{3-[4-(4-n-heptylbenzyloxy)phenyl]-1,2,4-oxadiazol-5-yl}phenyl 4-hexylbenzoate
CAS No.:1342883-91-3
Molecular Formula:C₄₁H₄₆N₂O₄
Molecular Weight:630.827
Hs Code.:

Synonyms:4-{3-[4-(4-n-heptylbenzyloxy)phenyl]-1,2,4-oxadiazol-5-yl}phenyl 4-hexylbenzoate

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Chemical Property of 4-{3-[4-(4-n-heptylbenzyloxy)phenyl]-1,2,4-oxadiazol-5-yl}phenyl 4-hexylbenzoate

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Technology Process of 4-{3-[4-(4-n-heptylbenzyloxy)phenyl]-1,2,4-oxadiazol-5-yl}phenyl 4-hexylbenzoate

There total 4 articles about 4-{3-[4-(4-n-heptylbenzyloxy)phenyl]-1,2,4-oxadiazol-5-yl}phenyl 4-hexylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 60982-74-3
4-n-heptylphenylmethyl bromide

: 1342883-62-8
4-[3-(4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]phenyl 4-hexyl-benzoate

: 1342883-91-3
4-{3-[4-(4-n-heptylbenzyloxy)phenyl]-1,2,4-oxadiazol-5-yl}phenyl 4-hexylbenzoate

Guidance literature:: With potassium carbonate; In butanone; for 10h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2011.09.039

Reference yield:

: 62536-94-1
4-benzyloxy-N'-hydroxybenzimidamide

: 1342883-91-3
4-{3-[4-(4-n-heptylbenzyloxy)phenyl]-1,2,4-oxadiazol-5-yl}phenyl 4-hexylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexyl-carbodiimide / 1,4-dioxane / 9 h / 25 °C / Reflux

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethyl acetate / 6 h / 20 °C / 750.08 Torr

3: potassium carbonate / butanone / 10 h / Inert atmosphere; Reflux

With palladium 10% on activated carbon; hydrogen; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; butanone; 3: Williamson etherification;
DOI:10.1016/j.tet.2011.09.039

Reference yield:

: 52805-36-4
4-benzyloxybenzonitrile

: 1342883-91-3
4-{3-[4-(4-n-heptylbenzyloxy)phenyl]-1,2,4-oxadiazol-5-yl}phenyl 4-hexylbenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride

2: dicyclohexyl-carbodiimide / 1,4-dioxane / 9 h / 25 °C / Reflux

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethyl acetate / 6 h / 20 °C / 750.08 Torr

4: potassium carbonate / butanone / 10 h / Inert atmosphere; Reflux

With palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; butanone; 4: Williamson etherification;
DOI:10.1016/j.tet.2011.09.039