4-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-N-(thiazol-2-yl)benzenesulfonamide monohydrochloride

Base Information

Chemical Name:4-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-N-(thiazol-2-yl)benzenesulfonamide monohydrochloride
CAS No.:1061768-00-0
Molecular Formula:C₁₉H₁₆ClN₅O₄S₂*ClH
Molecular Weight:514.413
Hs Code.:

Synonyms:4-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-N-(thiazol-2-yl)benzenesulfonamide monohydrochloride

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Chemical Property of 4-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-N-(thiazol-2-yl)benzenesulfonamide monohydrochloride

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Technology Process of 4-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-N-(thiazol-2-yl)benzenesulfonamide monohydrochloride

There total 3 articles about 4-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-N-(thiazol-2-yl)benzenesulfonamide monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 27631-29-4
2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

: 72-14-0
Sulfathiazole

: 1061768-00-0
4-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-N-(thiazol-2-yl)benzenesulfonamide monohydrochloride

Guidance literature:: In isopropyl alcohol; for 2h; Heating;
DOI:10.1016/j.bmc.2008.07.038

Reference yield:

: 28888-44-0
6,7-dimethoxy-1H-quinazoline-2,4-dione

: 1061768-00-0
4-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-N-(thiazol-2-yl)benzenesulfonamide monohydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 24 h / 100 °C

2: isopropyl alcohol / 24 h / Reflux

With trichlorophosphate; In isopropyl alcohol;
DOI:10.1016/j.ejmech.2013.10.058

Reference yield:

: 5653-40-7
2-Amino-4,5-dimethoxybenzoic acid

: 1061768-00-0
4-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-N-(thiazol-2-yl)benzenesulfonamide monohydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / water / 0.25 h / 35 °C

1.2: 0.25 h / 35 °C

1.3: 20 °C / pH 4

2.1: trichlorophosphate / 24 h / 100 °C

3.1: isopropyl alcohol / 24 h / Reflux

With acetic acid; trichlorophosphate; In water; isopropyl alcohol;
DOI:10.1016/j.ejmech.2013.10.058