[4-(2-nitrobenzenesulfonyl)-4,7,17-triazabicyclo[11.3.1]heptadeca-1⁽¹⁷⁾,13,15-trien-7-yl]phosphoramidic acid diethyl ester

Base Information

• Chemical Name: [4-(2-nitrobenzenesulfonyl)-4,7,17-triazabicyclo[11.3.1]heptadeca-1⁽¹⁷⁾,13,15-trien-7-yl]phosphoramidic acid diethyl ester
• CAS No.: 404034-86-2
• Molecular Formula: C₂₄H₃₅N₄O₇PS
• Molecular Weight: 554.604

Synonyms:[4-(2-nitrobenzenesulfonyl)-4,7,17-triazabicyclo[11.3.1]heptadeca-1⁽¹⁷⁾,13,15-trien-7-yl]phosphoramidic acid diethyl ester

Chemical Property of [4-(2-nitrobenzenesulfonyl)-4,7,17-triazabicyclo[11.3.1]heptadeca-1⁽¹⁷⁾,13,15-trien-7-yl]phosphoramidic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(2-nitrobenzenesulfonyl)-4,7,17-triazabicyclo[11.3.1]heptadeca-1⁽¹⁷⁾,13,15-trien-7-yl]phosphoramidic acid diethyl ester

There total 8 articles about [4-(2-nitrobenzenesulfonyl)-4,7,17-triazabicyclo[11.3.1]heptadeca-1⁽¹⁷⁾,13,15-trien-7-yl]phosphoramidic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

diethyl chlorophosphate (814-49-3) + 4-(2-nitrobenzenesulfonyl)-4,7,17-triazabicyclo[11.3.1]heptadeca-1(17),13,15-triene (404034-85-1) → [4-(2-nitrobenzenesulfonyl)-4,7,17-triazabicyclo[11.3.1]heptadeca-1(17),13,15-trien-7-yl]phosphoramidic acid diethyl ester (404034-86-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jo0109523

Reference yield:

2-(6-bromopyridin-2-yl)acetonitrile (112575-11-8) → [4-(2-nitrobenzenesulfonyl)-4,7,17-triazabicyclo[11.3.1]heptadeca-1(17),13,15-trien-7-yl]phosphoramidic acid diethyl ester (404034-86-2)

Guidance literature:

Multi-step reaction with 8 steps

1: BF₃*THF / tetrahydrofuran / 18 h / 60 °C

2: 6.3 g / Et₃N / CH₂Cl₂ / 20 °C

3: (Ph₃P)2PdCl₂ / tetrahydrofuran

4: BH₃*Me₂S / tetrahydrofuran / 4 h / 60 °C

5: 311 mg / Na₂CO₃ / tetrahydrofuran / 2 h / -15 °C

6: 84 percent / K₂CO₃ / acetonitrile / 18 h / 60 °C

7: 70 percent / BH₃*THF / tetrahydrofuran / 50 °C

8: 77 percent / Et₃N / CH₂Cl₂ / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; borane-THF; boron trifluoride-tetrahydrofuran complex; dimethylsulfide borane complex; sodium carbonate; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1021/jo0109523

Reference yield:

2-(6-bromopyridin-2-yl)ethylamine (404034-81-7) → [4-(2-nitrobenzenesulfonyl)-4,7,17-triazabicyclo[11.3.1]heptadeca-1(17),13,15-trien-7-yl]phosphoramidic acid diethyl ester (404034-86-2)

Guidance literature:

Multi-step reaction with 7 steps

1: 6.3 g / Et₃N / CH₂Cl₂ / 20 °C

2: (Ph₃P)2PdCl₂ / tetrahydrofuran

3: BH₃*Me₂S / tetrahydrofuran / 4 h / 60 °C

4: 311 mg / Na₂CO₃ / tetrahydrofuran / 2 h / -15 °C

5: 84 percent / K₂CO₃ / acetonitrile / 18 h / 60 °C

6: 70 percent / BH₃*THF / tetrahydrofuran / 50 °C

7: 77 percent / Et₃N / CH₂Cl₂ / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; borane-THF; dimethylsulfide borane complex; sodium carbonate; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1021/jo0109523

upstream raw materials:

diethyl chlorophosphate

4-(2-nitrobenzenesulfonyl)-4,7,17-triazabicyclo[11.3.1]heptadeca-1⁽¹⁷⁾,13,15-triene

2-(6-bromopyridin-2-yl)acetonitrile

2-(6-bromopyridin-2-yl)ethylamine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 404034-86-2 [4-(2-nitrobenzenesulfonyl)-4,7,17-triazabicyclo[11.3.1]heptadeca-1⁽¹⁷⁾,13,15-trien-7-yl]phosphoramidic acid diethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send