3-Benzyloxy-N-[2-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylcarbamoyl)-ethyl]-4-methyl-2-nitro-benzamide

Base Information

• Chemical Name: 3-Benzyloxy-N-[2-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylcarbamoyl)-ethyl]-4-methyl-2-nitro-benzamide
• CAS No.: 211674-40-7
• Molecular Formula: C₃₄H₄₁N₃O₁₁
• Molecular Weight: 667.713
• Mol file: 211674-40-7.mol

Synonyms:3-Benzyloxy-N-[2-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylcarbamoyl)-ethyl]-4-methyl-2-nitro-benzamide

Chemical Property of 3-Benzyloxy-N-[2-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylcarbamoyl)-ethyl]-4-methyl-2-nitro-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Benzyloxy-N-[2-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylcarbamoyl)-ethyl]-4-methyl-2-nitro-benzamide

There total 6 articles about 3-Benzyloxy-N-[2-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylcarbamoyl)-ethyl]-4-methyl-2-nitro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

3-(3-Benzyloxy-4-methyl-2-nitro-benzoylamino)-propionyl azide (87590-36-1) + 4-aminobenzo-18-crown-6 (68941-06-0) → 3-Benzyloxy-N-[2-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylcarbamoyl)-ethyl]-4-methyl-2-nitro-benzamide (211674-40-7)

Guidance literature:

In diethyl ether; chloroform;

Reference yield:

2-nitro-3-benzyloxy-4-methylbenzoyl chloride (7536-35-8) + 3-amino-N-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-yl)-propionamide → 3-Benzyloxy-N-[2-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylcarbamoyl)-ethyl]-4-methyl-2-nitro-benzamide (211674-40-7)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 20 ℃; for 18h;

DOI:10.1134/S1070363216120070

Reference yield:

4'-nitrobenzo-18-crown-6 (53408-96-1) → 3-Benzyloxy-N-[2-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylcarbamoyl)-ethyl]-4-methyl-2-nitro-benzamide (211674-40-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / dioxane

2: 55 percent / diethyl ether; CHCl₃

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; chloroform;

upstream raw materials:

3-(3-Benzyloxy-4-methyl-2-nitro-benzoylamino)-propionyl azide

4-aminobenzo-18-crown-6

4'-nitrobenzo-18-crown-6

3-Benzyloxy-N-(2-hydrazinocarbonyl-ethyl)-4-methyl-2-nitro-benzamide