2-methyl-6-(p-tolyl)-3-phenylsulphinylheptan-4-one

Base Information

• Chemical Name: 2-methyl-6-(p-tolyl)-3-phenylsulphinylheptan-4-one
• CAS No.: 98711-79-6
• Molecular Formula: C₂₁H₂₆O₂S
• Molecular Weight: 342.502
• Mol file: 98711-79-6.mol

Synonyms:2-methyl-6-(p-tolyl)-3-phenylsulphinylheptan-4-one

Chemical Property of 2-methyl-6-(p-tolyl)-3-phenylsulphinylheptan-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-6-(p-tolyl)-3-phenylsulphinylheptan-4-one

There total 10 articles about 2-methyl-6-(p-tolyl)-3-phenylsulphinylheptan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-methyl-6-(p-tolyl)-3-phenylthioheptan-4-one (88065-35-4) → 2-methyl-6-(p-tolyl)-3-phenylsulphinylheptan-4-one (98711-79-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In ethanol; at 0 ℃; for 0.5h;

DOI:10.1039/P19850001237

Reference yield:

ethyl (E)-3-p-tolylbut-2-enoate (6305-61-9,115819-11-9,94853-53-9) → 2-methyl-6-(p-tolyl)-3-phenylsulphinylheptan-4-one (98711-79-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 96 percent / hydrogen / 5percent palladium on charcoal / ethanol / 6 h / 760 Torr

2: 85 percent / lithium aluminium hydride / tetrahydrofuran / 0.5 h

3: 57 percent / pyridinium chlorochromate / CH₂Cl₂ / 1.5 h / other reagent

4: 1.) n-butyl-lithium, TMEDA 2.) n-butyl-lithium / 1.) hexane, THF, 0 deg C, 15 min 2.) 30 min, hexane, THF

5: 23 percent / toluene-p-sulphonic acid / benzene / 0.02 h

6: 64 percent / MCPBA / ethanol / 0.5 h / 0 °C

With lithium aluminium tetrahydride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; benzene;

DOI:10.1039/P19850001237

Reference yield:

para-methylacetophenone (122-00-9) → 2-methyl-6-(p-tolyl)-3-phenylsulphinylheptan-4-one (98711-79-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) sodium hydride / 1.) dimethoxyethane, 30 min, room temperature 2.) reflux, 5 h, dimethoxy ethane

2: 96 percent / hydrogen / 5percent palladium on charcoal / ethanol / 6 h / 760 Torr

3: 85 percent / lithium aluminium hydride / tetrahydrofuran / 0.5 h

4: 57 percent / pyridinium chlorochromate / CH₂Cl₂ / 1.5 h / other reagent

5: 1.) n-butyl-lithium, TMEDA 2.) n-butyl-lithium / 1.) hexane, THF, 0 deg C, 15 min 2.) 30 min, hexane, THF

6: 23 percent / toluene-p-sulphonic acid / benzene / 0.02 h

7: 64 percent / MCPBA / ethanol / 0.5 h / 0 °C

With lithium aluminium tetrahydride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen; sodium hydride; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; benzene;

DOI:10.1039/P19850001237

upstream raw materials:

isobutyl phenyl sulfoxide

(+/-)-ethyl 3-(4-methylphenyl)butanoate

2-methyl-6-(p-tolyl)-3-phenylthioheptan-4-one

3-(p-tolyl)-butyraldehyde

Downstream raw materials:

(+/-)-ar-turmerone