(+/-)-N-benzyl-2-[7-(benzyloxy)-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-N-methylacetamide

Base Information

Chemical Name:(+/-)-N-benzyl-2-[7-(benzyloxy)-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-N-methylacetamide
CAS No.:1253197-39-5
Molecular Formula:C₂₇H₃₀N₂O₃
Molecular Weight:430.547
Hs Code.:

Synonyms:(+/-)-N-benzyl-2-[7-(benzyloxy)-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-N-methylacetamide

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Chemical Property of (+/-)-N-benzyl-2-[7-(benzyloxy)-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-N-methylacetamide

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Technology Process of (+/-)-N-benzyl-2-[7-(benzyloxy)-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-N-methylacetamide

There total 9 articles about (+/-)-N-benzyl-2-[7-(benzyloxy)-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1253197-26-0
(+/-)-7-benzyloxy-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

: 73685-56-0
N-benzyl-N-methyl-α-chloroacetamide

: 1253197-39-5
(+/-)-N-benzyl-2-[7-(benzyloxy)-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-N-methylacetamide

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetonitrile; for 50h; Reflux;
DOI:10.1016/j.bmc.2010.09.026

Reference yield:

: 81593-56-8
[[2-(3-Methoxy-phenyl)-ethyl]-(toluene-4-sulfonyl)-amino]-acetic acid

: 1253197-39-5
(+/-)-N-benzyl-2-[7-(benzyloxy)-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-N-methylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: phosphorus pentoxide / 1,2-dichloro-ethane / 24 h / 0 °C / Inert atmosphere

2.1: aluminum (III) chloride / dichloromethane / 23 h / Reflux

2.2: 1 h / Cooling with ice

3.1: potassium carbonate / acetone / 4 h / Reflux

4.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

5.1: methanol; magnesium / 5 h / Reflux

6.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 50 h / Reflux

With methanol; aluminum (III) chloride; sodium tetrahydroborate; phosphorus pentoxide; tetra-(n-butyl)ammonium iodide; potassium carbonate; magnesium; In dichloromethane; 1,2-dichloro-ethane; acetone; acetonitrile;

Reference yield:

: 81593-57-9
7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one

: 1253197-39-5
(+/-)-N-benzyl-2-[7-(benzyloxy)-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-N-methylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / dichloromethane / 23 h / Reflux

1.2: 1 h / Cooling with ice

2.1: potassium carbonate / acetone / 4 h / Reflux

3.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

4.1: methanol; magnesium / 5 h / Reflux

5.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 50 h / Reflux

With methanol; aluminum (III) chloride; sodium tetrahydroborate; tetra-(n-butyl)ammonium iodide; potassium carbonate; magnesium; In dichloromethane; acetone; acetonitrile;