N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-phenylacetamido-morpholin-2-yl]-acetamide benzyl ester

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Chemical Name:N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-phenylacetamido-morpholin-2-yl]-acetamide benzyl ester
CAS No.:609846-81-3
Molecular Formula:C₃₀H₃₁N₅O₆
Molecular Weight:557.606
Hs Code.:

Synonyms:N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-phenylacetamido-morpholin-2-yl]-acetamide benzyl ester

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Chemical Property of N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-phenylacetamido-morpholin-2-yl]-acetamide benzyl ester

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Technology Process of N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-phenylacetamido-morpholin-2-yl]-acetamide benzyl ester

There total 8 articles about N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-phenylacetamido-morpholin-2-yl]-acetamide benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 441764-53-0
(R)-2-(2-oxo-ethoxy)-succinic acid dimethyl ester

: 609846-81-3
N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-phenylacetamido-morpholin-2-yl]-acetamide benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: toluene / 65 °C

2: H₂ / Pd/C / tetrahydrofuran / 18 h

3: H₂O / 7 h / 60 °C

4: 49 percent / pyridine / 29 h

5: aq. LiOH / methanol

6: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; DIPEA / dimethylformamide / 1.67 h

With pyridine; lithium hydroxide; water; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0307990

Reference yield:

: 441764-51-8
(R)-2-allyloxysuccinic acid dimethyl ester

: 609846-81-3
N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-phenylacetamido-morpholin-2-yl]-acetamide benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: OsO₄; N-methyl morpholine-N-oxide / tetrahydrofuran; H₂O

2: NaIO₄ / tetrahydrofuran; H₂O

3: toluene / 65 °C

4: H₂ / Pd/C / tetrahydrofuran / 18 h

5: H₂O / 7 h / 60 °C

6: 49 percent / pyridine / 29 h

7: aq. LiOH / methanol

8: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; DIPEA / dimethylformamide / 1.67 h

With pyridine; lithium hydroxide; sodium periodate; osmium(VIII) oxide; water; hydrogen; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; HATU; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0307990

Reference yield:

: (R)-2-(2,3-Dihydroxy-propoxy)-succinic acid dimethyl ester

: 609846-81-3
N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-phenylacetamido-morpholin-2-yl]-acetamide benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: NaIO₄ / tetrahydrofuran; H₂O

2: toluene / 65 °C

3: H₂ / Pd/C / tetrahydrofuran / 18 h

4: H₂O / 7 h / 60 °C

5: 49 percent / pyridine / 29 h

6: aq. LiOH / methanol

7: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; DIPEA / dimethylformamide / 1.67 h

With pyridine; lithium hydroxide; sodium periodate; water; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0307990