4-<3-<2-(1-piperidinyl)phenyl>-2,2-ethylenedioxy-heptyl>-benzoic acid

Base Information

• Chemical Name: 4-<3-<2-(1-piperidinyl)phenyl>-2,2-ethylenedioxy-heptyl>-benzoic acid
• CAS No.: 219922-80-2
• Molecular Formula: C₂₇H₃₅NO₄
• Molecular Weight: 437.579
• Mol file: 219922-80-2.mol

Synonyms:4-<3-<2-(1-piperidinyl)phenyl>-2,2-ethylenedioxy-heptyl>-benzoic acid

Chemical Property of 4-<3-<2-(1-piperidinyl)phenyl>-2,2-ethylenedioxy-heptyl>-benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<3-<2-(1-piperidinyl)phenyl>-2,2-ethylenedioxy-heptyl>-benzoic acid

There total 9 articles about 4-<3-<2-(1-piperidinyl)phenyl>-2,2-ethylenedioxy-heptyl>-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(piperidin-1-yl)benzonitrile (72752-52-4) → 4-<3-<2-(1-piperidinyl)phenyl>-2,2-ethylenedioxy-heptyl>-benzoic acid (219922-80-2)

Guidance literature:

Multi-step reaction with 9 steps

1: tetrahydrofuran; toluene / 3 h / Heating

2: 4N aq. HCl / toluene; tetrahydrofuran / 20 °C

3: 23 percent / diethyl ether / 1.) 40 deg C, 5 h, 2.) RT, 5 d

4: 96 percent / H₂ / 10 percent Pd/C / ethanol / 750.06 Torr / Ambient temperature

5: 1.) NaOEt / 1.) EtOH, 50 deg C, 2.) EtOH, a) reflux, 2 h, b) RT, overnight

6: H₂SO₄ / 0.08 h / 80 °C

7: aq. H₂SO₄ / 1 h / 110 °C

8: 88 percent / p-TsOH*H₂O / benzene / 72 h / Heating

9: 1.) n-BuLi / 1.) Et₂O, hexane, 25 deg C, 30 min, 2.) Et₂O, hexane, RT, overnight

With hydrogenchloride; n-butyllithium; sulfuric acid; hydrogen; sodium ethanolate; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; toluene; benzene;

DOI:10.1021/jm9810349

Reference yield:

piperidine (110-89-4) → 4-<3-<2-(1-piperidinyl)phenyl>-2,2-ethylenedioxy-heptyl>-benzoic acid (219922-80-2)

Guidance literature:

Multi-step reaction with 10 steps

1: 84 percent / N-formyl-piperidine / 64 h / 160 - 170 °C

2: tetrahydrofuran; toluene / 3 h / Heating

3: 4N aq. HCl / toluene; tetrahydrofuran / 20 °C

4: 23 percent / diethyl ether / 1.) 40 deg C, 5 h, 2.) RT, 5 d

5: 96 percent / H₂ / 10 percent Pd/C / ethanol / 750.06 Torr / Ambient temperature

6: 1.) NaOEt / 1.) EtOH, 50 deg C, 2.) EtOH, a) reflux, 2 h, b) RT, overnight

7: H₂SO₄ / 0.08 h / 80 °C

8: aq. H₂SO₄ / 1 h / 110 °C

9: 88 percent / p-TsOH*H₂O / benzene / 72 h / Heating

10: 1.) n-BuLi / 1.) Et₂O, hexane, 25 deg C, 30 min, 2.) Et₂O, hexane, RT, overnight

With N-Formylpiperidine; hydrogenchloride; n-butyllithium; sulfuric acid; hydrogen; sodium ethanolate; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; toluene; benzene;

DOI:10.1021/jm9810349

Reference yield:

n-propyl-(2-piperidino-phenyl)-ketone (219921-99-0) → 4-<3-<2-(1-piperidinyl)phenyl>-2,2-ethylenedioxy-heptyl>-benzoic acid (219922-80-2)

Guidance literature:

Multi-step reaction with 7 steps

1: 23 percent / diethyl ether / 1.) 40 deg C, 5 h, 2.) RT, 5 d

2: 96 percent / H₂ / 10 percent Pd/C / ethanol / 750.06 Torr / Ambient temperature

3: 1.) NaOEt / 1.) EtOH, 50 deg C, 2.) EtOH, a) reflux, 2 h, b) RT, overnight

4: H₂SO₄ / 0.08 h / 80 °C

5: aq. H₂SO₄ / 1 h / 110 °C

6: 88 percent / p-TsOH*H₂O / benzene / 72 h / Heating

7: 1.) n-BuLi / 1.) Et₂O, hexane, 25 deg C, 30 min, 2.) Et₂O, hexane, RT, overnight

With n-butyllithium; sulfuric acid; hydrogen; sodium ethanolate; toluene-4-sulfonic acid; palladium on activated charcoal; In diethyl ether; ethanol; benzene;

DOI:10.1021/jm9810349

upstream raw materials:

piperidine

2-(piperidin-1-yl)benzonitrile

n-propyl-(2-piperidino-phenyl)-ketone

1-(2-piperidin-1-yl-phenyl)-butylideneamine

Downstream raw materials:

methyl 4-<4-<2-(1-piperidinyl)phenyl>-2,2-ethylenedithio-heptyl>-benzoate

methyl 4-<4-<2-(1-piperidinyl)phenyl>-heptyl>-benzoate

4-[2-oxo-4-(2-piperidin-1-yl-phenyl)-heptyl]-benzoic acid