(E)-N-[4-(4-chlorophenyl)-3-cyanothiophen-2-yl]-2-cyano-3-dimethylaminoacrylamide

Base Information

Chemical Name:(E)-N-[4-(4-chlorophenyl)-3-cyanothiophen-2-yl]-2-cyano-3-dimethylaminoacrylamide
CAS No.:1375398-83-6
Molecular Formula:C₁₇H₁₃ClN₄OS
Molecular Weight:356.835
Hs Code.:

Synonyms:(E)-N-[4-(4-chlorophenyl)-3-cyanothiophen-2-yl]-2-cyano-3-dimethylaminoacrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-N-[4-(4-chlorophenyl)-3-cyanothiophen-2-yl]-2-cyano-3-dimethylaminoacrylamide

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Technology Process of (E)-N-[4-(4-chlorophenyl)-3-cyanothiophen-2-yl]-2-cyano-3-dimethylaminoacrylamide

There total 2 articles about (E)-N-[4-(4-chlorophenyl)-3-cyanothiophen-2-yl]-2-cyano-3-dimethylaminoacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1375398-74-5
N-[4-(4-chlorophenyl)-3-cyanothiophen-2-yl]-2-cyanoacetamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1375398-83-6
(E)-N-[4-(4-chlorophenyl)-3-cyanothiophen-2-yl]-2-cyano-3-dimethylaminoacrylamide

Guidance literature:: In 1,4-dioxane; for 2h; Reflux;
DOI:10.1016/j.ejmech.2012.03.004

Reference yield:

: 86604-36-6
2-amino-4-(4-chlorophenyl)-3-thiophenecarbonitrile

: 1375398-83-6
(E)-N-[4-(4-chlorophenyl)-3-cyanothiophen-2-yl]-2-cyano-3-dimethylaminoacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic anhydride / 0 h / 85 °C / Microwave irradiation

1.2: 0.01 h / 100 °C / Microwave irradiation

2.1: 1,4-dioxane / 2 h / Reflux

With acetic anhydride; In 1,4-dioxane;
DOI:10.1016/j.ejmech.2012.03.004