(2S,1’S)-2-[(4-chlorophenyl)(phenylamino)methyl]cyclohexanone

Base Information

• Chemical Name: (2S,1’S)-2-[(4-chlorophenyl)(phenylamino)methyl]cyclohexanone
• CAS No.: 1215119-69-9
• Molecular Formula: C₁₉H₂₀ClNO
• Molecular Weight: 313.827
• Mol file: 1215119-69-9.mol

Synonyms:(2S,1’S)-2-[(4-chlorophenyl)(phenylamino)methyl]cyclohexanone

Chemical Property of (2S,1’S)-2-[(4-chlorophenyl)(phenylamino)methyl]cyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,1’S)-2-[(4-chlorophenyl)(phenylamino)methyl]cyclohexanone

There total 4 articles about (2S,1’S)-2-[(4-chlorophenyl)(phenylamino)methyl]cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

1-(2,2,2-trichloroacetoxy)cyclohexene (22780-11-6) + N-(4-chlorobenzylidene)aniline (2362-79-0) → (2S,1’S)-2-[(4-chlorophenyl)(phenylamino)methyl]cyclohexanone (1215119-69-9)

Guidance literature:

With 2,2,2-trifluoroethanol; silver trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; (R)-segphos; In tetrahydrofuran; at -30 ℃; for 8h; enantioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1021/ol403075u

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 4-chlorobenzaldehyde (104-88-1) + aniline (62-53-3) → (2S,1’S)-2-[(4-chlorophenyl)(phenylamino)methyl]cyclohexanone (1215119-69-9) + 2-[(4-chlorophenyl)(phenylamino)methyl]cyclohexanone

Guidance literature:

With methyl 2-amino-4,6-O-benzylidene-2-deoxy-α-D-glucopyranoside; benzoic acid; In dichloromethane; at 20 ℃; for 48h; Overall yield = 83 %; Overall yield = 52 mg; stereoselective reaction;

DOI:10.1055/s-0036-1591740

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 4-chlorobenzaldehyde (104-88-1) + aniline (62-53-3) → (2S,1’S)-2-[(4-chlorophenyl)(phenylamino)methyl]cyclohexanone (1215119-69-9) + (R)-2-((R)-(4-chlorophenyl)(phenylamino)methyl)cyclohexanone (1393116-38-5) + 2-((4-chlorophenyl)(phenylamino)methyl)cyclohexanone

Guidance literature:

With acylase I from Aspergillus melleus; In aq. phosphate buffer; acetonitrile; at 30 ℃; for 166h; pH=8.1; Overall yield = 81 %; stereoselective reaction; Green chemistry; Enzymatic reaction;

DOI:10.1016/j.molcatb.2014.11.007

upstream raw materials:

1-(2,2,2-trichloroacetoxy)cyclohexene

N-(4-chlorobenzylidene)aniline

cyclohexanone

4-chlorobenzaldehyde