3'-(benzylamino)-2'-O,3'-N-carbonyl-3'-deoxy-2-[(dimethylamino)methylidene]guanosine

Base Information

Chemical Name:3'-(benzylamino)-2'-O,3'-N-carbonyl-3'-deoxy-2-[(dimethylamino)methylidene]guanosine
CAS No.:557771-62-7
Molecular Formula:C₂₁H₂₃N₇O₅
Molecular Weight:453.458
Hs Code.:

Synonyms:3'-(benzylamino)-2'-O,3'-N-carbonyl-3'-deoxy-2-[(dimethylamino)methylidene]guanosine

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Chemical Property of 3'-(benzylamino)-2'-O,3'-N-carbonyl-3'-deoxy-2-[(dimethylamino)methylidene]guanosine

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Technology Process of 3'-(benzylamino)-2'-O,3'-N-carbonyl-3'-deoxy-2-[(dimethylamino)methylidene]guanosine

There total 7 articles about 3'-(benzylamino)-2'-O,3'-N-carbonyl-3'-deoxy-2-[(dimethylamino)methylidene]guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.4%

: 557771-61-6
2'-O-[(benzylamino)carbonyl]-3'-bromo-5'-O-[(tert-butyl)diphenylsilyl]-3'-deoxy-2-[(dimethylamino)methylidene]guanosine

: 557771-62-7
3'-(benzylamino)-2'-O,3'-N-carbonyl-3'-deoxy-2-[(dimethylamino)methylidene]guanosine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at -15 - 20 ℃; for 28h;
DOI:10.1002/hlca.200390069

Reference yield: 87.0%

: C₃₇H₄₁N₇O₅Si

: 557771-62-7
3'-(benzylamino)-2'-O,3'-N-carbonyl-3'-deoxy-2-[(dimethylamino)methylidene]guanosine

Guidance literature:: With triethylamine tris(hydrogen fluoride); In acetonitrile; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/acs.joc.1c00984

Reference yield:

: 17331-16-7
N²-(dimethylaminomethylene)guanosine

: 557771-62-7
3'-(benzylamino)-2'-O,3'-N-carbonyl-3'-deoxy-2-[(dimethylamino)methylidene]guanosine

Guidance literature:: Multi-step reaction with 5 steps

1: 96.2 percent / DMAP / pyridine / 72 h

2: 82.8 percent / H₂O / acetonitrile / 6 h / 0 - 20 °C

3: 89.7 percent / NH₃ / methanol / 1.5 h / 20 °C

4: 93.7 percent / Et₃N / tetrahydrofuran / 60 h / 20 °C

5: 91.4 percent / NaH / dimethylformamide / 28 h / -15 - 20 °C

With dmap; ammonia; water; sodium hydride; triethylamine; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide; acetonitrile; 2: Moffatt reaction;
DOI:10.1002/hlca.200390069