C₆₄H₉₁N₅O₁₂Si

Base Information

Chemical Name:C₆₄H₉₁N₅O₁₂Si
CAS No.:916913-02-5
Molecular Formula:C₆₄H₉₁N₅O₁₂Si
Molecular Weight:1150.54
Hs Code.:

C<sub>64</sub>H<sub>91</sub>N<sub>5</sub>O<sub>12</sub>Si

Synonyms:C₆₄H₉₁N₅O₁₂Si

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Chemical Property of C₆₄H₉₁N₅O₁₂Si

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Technology Process of C₆₄H₉₁N₅O₁₂Si

There total 30 articles about C₆₄H₉₁N₅O₁₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38836-21-4,65651-63-0
(S)-4-hydroxy-5-methylhexan-2-one

: 916913-02-5
C₆₄H₉₁N₅O₁₂Si

Guidance literature:: Multi-step reaction with 18 steps

1.1: 42.55 g / imidazole / dimethylformamide / 24 h

2.1: LDA / hexane; tetrahydrofuran / 0.33 h / -78 °C

2.2: hexane; tetrahydrofuran / 1 h / -78 °C

3.1: 8.35 g / aq. HF / acetonitrile / 20 °C

4.1: H₂ / Pd/C / dioxane / 12 h / 20 °C / 760 Torr

4.2: 83 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

5.1: pyridine / CH₂Cl₂ / 0 °C

6.1: aq. K₂CO₃ / methanol / 5 h

7.1: Dess-Martin reagent / CH₂Cl₂ / 3 h / 0 °C

8.1: CF₃SO₃H; Et₃B; DIPEA / hexane; CH₂Cl₂ / 0.5 h / -10 °C

8.2: 91 percent / TiCl₄ / hexane; CH₂Cl₂ / 2 h

9.1: LiAlH₄ / tetrahydrofuran / 0.5 h / Heating

10.1: PPTs / 24 h

11.1: 82 percent / 2,4,6-trichlorobenzoyl chloride; DIPEA; DMAP / benzene

12.1: TsOH / methanol

13.1: 2,2,6,6-tetramethylpiperidinyloxyl; KBr; NaHCO₃ / NaClO / CH₂Cl₂; H₂O / 1 h

14.1: NaClO₂; NaH₂PO₄ / H₂O; 2-methyl-propan-2-ol; various solvent(s) / 1 h

15.1: HATU; DIPEA / CH₂Cl₂ / 24 h

16.1: 86 percent / (diethylamino)sulfur trifluoride / CH₂Cl₂ / 3 h / -78 °C

17.1: N-methylaniline / [Pd(PPh₃)4] / tetrahydrofuran / 2 h

18.1: HATU; DIPEA / CH₂Cl₂ / 48 h / 20 °C

With pyridine; 1H-imidazole; dmap; sodium chlorite; sodium dihydrogenphosphate; lithium aluminium tetrahydride; 4-oxo-2,2,6,6-tetramethylpiperidin-oxyl; triethyl borane; trifluorormethanesulfonic acid; diethylamino-sulfur trifluoride; 2,4,6-trichlorobenzoyl chloride; hydrogen fluoride; hydrogen; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; N-methylaniline; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium bromide; lithium diisopropyl amide; sodium hypochlorite; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; benzene; 2.2: Peterson reaction / 7.1: Dess-Martin oxidation;
DOI:10.1002/chem.200600599

Reference yield:

: 916912-79-3
4-(tert-butyl-dimethyl-silanyloxy)-5-methyl-hexan-2-one

: 916913-02-5
C₆₄H₉₁N₅O₁₂Si

Guidance literature:: Multi-step reaction with 17 steps

1.1: LDA / hexane; tetrahydrofuran / 0.33 h / -78 °C

1.2: hexane; tetrahydrofuran / 1 h / -78 °C

2.1: 8.35 g / aq. HF / acetonitrile / 20 °C

3.1: H₂ / Pd/C / dioxane / 12 h / 20 °C / 760 Torr

3.2: 83 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

4.1: pyridine / CH₂Cl₂ / 0 °C

5.1: aq. K₂CO₃ / methanol / 5 h

6.1: Dess-Martin reagent / CH₂Cl₂ / 3 h / 0 °C

7.1: CF₃SO₃H; Et₃B; DIPEA / hexane; CH₂Cl₂ / 0.5 h / -10 °C

7.2: 91 percent / TiCl₄ / hexane; CH₂Cl₂ / 2 h

8.1: LiAlH₄ / tetrahydrofuran / 0.5 h / Heating

9.1: PPTs / 24 h

10.1: 82 percent / 2,4,6-trichlorobenzoyl chloride; DIPEA; DMAP / benzene

11.1: TsOH / methanol

12.1: 2,2,6,6-tetramethylpiperidinyloxyl; KBr; NaHCO₃ / NaClO / CH₂Cl₂; H₂O / 1 h

13.1: NaClO₂; NaH₂PO₄ / H₂O; 2-methyl-propan-2-ol; various solvent(s) / 1 h

14.1: HATU; DIPEA / CH₂Cl₂ / 24 h

15.1: 86 percent / (diethylamino)sulfur trifluoride / CH₂Cl₂ / 3 h / -78 °C

16.1: N-methylaniline / [Pd(PPh₃)4] / tetrahydrofuran / 2 h

17.1: HATU; DIPEA / CH₂Cl₂ / 48 h / 20 °C

With pyridine; dmap; sodium chlorite; sodium dihydrogenphosphate; lithium aluminium tetrahydride; 4-oxo-2,2,6,6-tetramethylpiperidin-oxyl; triethyl borane; trifluorormethanesulfonic acid; diethylamino-sulfur trifluoride; 2,4,6-trichlorobenzoyl chloride; hydrogen fluoride; hydrogen; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; N-methylaniline; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium bromide; lithium diisopropyl amide; sodium hypochlorite; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; acetonitrile; tert-butyl alcohol; benzene; 1.2: Peterson reaction / 6.1: Dess-Martin oxidation;
DOI:10.1002/chem.200600599

Reference yield:

: 916912-59-9
(E)-(S)-5-(tert-Butyl-dimethyl-silanyloxy)-3,6-dimethyl-hept-2-enoic acid ethyl ester

: 916913-02-5
C₆₄H₉₁N₅O₁₂Si

Guidance literature:: Multi-step reaction with 16 steps

1.1: 8.35 g / aq. HF / acetonitrile / 20 °C

2.1: H₂ / Pd/C / dioxane / 12 h / 20 °C / 760 Torr

2.2: 83 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

3.1: pyridine / CH₂Cl₂ / 0 °C

4.1: aq. K₂CO₃ / methanol / 5 h

5.1: Dess-Martin reagent / CH₂Cl₂ / 3 h / 0 °C

6.1: CF₃SO₃H; Et₃B; DIPEA / hexane; CH₂Cl₂ / 0.5 h / -10 °C

6.2: 91 percent / TiCl₄ / hexane; CH₂Cl₂ / 2 h

7.1: LiAlH₄ / tetrahydrofuran / 0.5 h / Heating

8.1: PPTs / 24 h

9.1: 82 percent / 2,4,6-trichlorobenzoyl chloride; DIPEA; DMAP / benzene

10.1: TsOH / methanol

11.1: 2,2,6,6-tetramethylpiperidinyloxyl; KBr; NaHCO₃ / NaClO / CH₂Cl₂; H₂O / 1 h

12.1: NaClO₂; NaH₂PO₄ / H₂O; 2-methyl-propan-2-ol; various solvent(s) / 1 h

13.1: HATU; DIPEA / CH₂Cl₂ / 24 h

14.1: 86 percent / (diethylamino)sulfur trifluoride / CH₂Cl₂ / 3 h / -78 °C

15.1: N-methylaniline / [Pd(PPh₃)4] / tetrahydrofuran / 2 h

16.1: HATU; DIPEA / CH₂Cl₂ / 48 h / 20 °C

With pyridine; dmap; sodium chlorite; sodium dihydrogenphosphate; lithium aluminium tetrahydride; 4-oxo-2,2,6,6-tetramethylpiperidin-oxyl; triethyl borane; trifluorormethanesulfonic acid; diethylamino-sulfur trifluoride; 2,4,6-trichlorobenzoyl chloride; hydrogen fluoride; hydrogen; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; N-methylaniline; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium bromide; sodium hypochlorite; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; acetonitrile; tert-butyl alcohol; benzene; 5.1: Dess-Martin oxidation;
DOI:10.1002/chem.200600599