(3R,4S,5E)-4-methyl-1-phenyl-3-{[(1R)-1-(2,4,6-triisopropylphenyl)ethyl]oxy}hept-5-en-1-one

Base Information

Chemical Name:(3R,4S,5E)-4-methyl-1-phenyl-3-{[(1R)-1-(2,4,6-triisopropylphenyl)ethyl]oxy}hept-5-en-1-one
CAS No.:723336-98-9
Molecular Formula:C₃₁H₄₄O₂
Molecular Weight:448.689
Hs Code.:

Synonyms:(3R,4S,5E)-4-methyl-1-phenyl-3-{[(1R)-1-(2,4,6-triisopropylphenyl)ethyl]oxy}hept-5-en-1-one

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Chemical Property of (3R,4S,5E)-4-methyl-1-phenyl-3-{[(1R)-1-(2,4,6-triisopropylphenyl)ethyl]oxy}hept-5-en-1-one

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Technology Process of (3R,4S,5E)-4-methyl-1-phenyl-3-{[(1R)-1-(2,4,6-triisopropylphenyl)ethyl]oxy}hept-5-en-1-one

There total 1 articles about (3R,4S,5E)-4-methyl-1-phenyl-3-{[(1R)-1-(2,4,6-triisopropylphenyl)ethyl]oxy}hept-5-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 13735-81-4
1-styrenyloxytrimethylsilane

: 1,3,5-Triisopropyl-2-[(R)-1-((1E,3E)-2-methyl-penta-1,3-dienyloxy)-ethyl]-benzene

: 723336-98-9
(3R,4S,5E)-4-methyl-1-phenyl-3-{[(1R)-1-(2,4,6-triisopropylphenyl)ethyl]oxy}hept-5-en-1-one

: (3S,4R,5E)-4-methyl-1-phenyl-3-{[(1R)-1-(2,4,6-triisopropyl)phenylethyl]oxy}hept-5-en-1-one

Guidance literature:: 1-styrenyloxytrimethylsilane; 1,3,5-Triisopropyl-2-[(R)-1-((1E,3E)-2-methyl-penta-1,3-dienyloxy)-ethyl]-benzene; With sulfur dioxide; bis(trifluoromethanesulfonyl)amide; In dichloromethane; at -84 ℃; for 15h;

With potassium carbonate; triphenylphosphine; isopropyl alcohol; palladium diacetate; In acetonitrile; at 80 ℃; for 0.5h;
DOI:10.1021/jo0357622

Reference yield: 96.0%

: 723336-98-9
(3R,4S,5E)-4-methyl-1-phenyl-3-{[(1R)-1-(2,4,6-triisopropylphenyl)ethyl]oxy}hept-5-en-1-one

: 723337-03-9
(E)-(3R,4S)-3-Hydroxy-4-methyl-1-phenyl-hept-5-en-1-one

Guidance literature:: With methoxybenzene; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1021/jo0357622

Reference yield:

: 723336-98-9
(3R,4S,5E)-4-methyl-1-phenyl-3-{[(1R)-1-(2,4,6-triisopropylphenyl)ethyl]oxy}hept-5-en-1-one

: (3S,4S,6R)-3-Methyl-6-phenyl-tetrahydro-pyran-2,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96 percent / trifluoroacetic acid; anisole / CH₂Cl₂ / 4 h / 0 °C

2.1: BEt₃; NaBH₄ / tetrahydrofuran / -78 - 0 °C

3.1: O₃ / CH₂Cl₂

3.2: Me₂S / CH₂Cl₂

With sodium tetrahydroborate; triethyl borane; ozone; methoxybenzene; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0357622