1-(4-(4-(3-(4-(1-acetyl-4-(4-(3-chloropropoxy)phenyl)piperidin-4-yl)phenoxy)propoxy)-2-methoxyphenyl)-4-(4-hydroxyphenyl)piperidin-1-yl)ethanone

Base Information

Chemical Name:1-(4-(4-(3-(4-(1-acetyl-4-(4-(3-chloropropoxy)phenyl)piperidin-4-yl)phenoxy)propoxy)-2-methoxyphenyl)-4-(4-hydroxyphenyl)piperidin-1-yl)ethanone
CAS No.:1425732-63-3
Molecular Formula:C₄₅H₅₃ClN₂O₇
Molecular Weight:769.378
Hs Code.:

Synonyms:1-(4-(4-(3-(4-(1-acetyl-4-(4-(3-chloropropoxy)phenyl)piperidin-4-yl)phenoxy)propoxy)-2-methoxyphenyl)-4-(4-hydroxyphenyl)piperidin-1-yl)ethanone

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Chemical Property of 1-(4-(4-(3-(4-(1-acetyl-4-(4-(3-chloropropoxy)phenyl)piperidin-4-yl)phenoxy)propoxy)-2-methoxyphenyl)-4-(4-hydroxyphenyl)piperidin-1-yl)ethanone

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Technology Process of 1-(4-(4-(3-(4-(1-acetyl-4-(4-(3-chloropropoxy)phenyl)piperidin-4-yl)phenoxy)propoxy)-2-methoxyphenyl)-4-(4-hydroxyphenyl)piperidin-1-yl)ethanone

There total 10 articles about 1-(4-(4-(3-(4-(1-acetyl-4-(4-(3-chloropropoxy)phenyl)piperidin-4-yl)phenoxy)propoxy)-2-methoxyphenyl)-4-(4-hydroxyphenyl)piperidin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1425732-60-0
1-(4-(4-(3-(4-(1-acetyl-4-(4-((2-nitrobenzyl)oxy)phenyl)piperidin-4-yl)-3-methoxyphenoxy)propoxy)phenyl)-4-(4-(3-chloropropoxy)phenyl)piperidin-1-yl)ethanone

: 1425732-63-3
1-(4-(4-(3-(4-(1-acetyl-4-(4-(3-chloropropoxy)phenyl)piperidin-4-yl)phenoxy)propoxy)-2-methoxyphenyl)-4-(4-hydroxyphenyl)piperidin-1-yl)ethanone

Guidance literature:: With 2,6-di-tert-butyl-4-methyl-phenol; In tetrahydrofuran; at 20 ℃; Irradiation;
DOI:10.1002/chem.201202498

Reference yield:

: 158984-57-7
1-(4-hydroxy-4-(4-methoxyphenyl)piperidin-1-yl)ethanone

: 1425732-63-3
1-(4-(4-(3-(4-(1-acetyl-4-(4-(3-chloropropoxy)phenyl)piperidin-4-yl)phenoxy)propoxy)-2-methoxyphenyl)-4-(4-hydroxyphenyl)piperidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: boron tribromide / dichloromethane / 3 h / Inert atmosphere; Reflux

2: potassium carbonate / acetonitrile / 6.5 h / Inert atmosphere; Reflux

3: boron trifluoride diethyl etherate / dichloromethane / 216 h / 20 °C / Darkness

4: caesium carbonate / acetone / 40 °C

5: 2,6-di-tert-butyl-4-methyl-phenol / tetrahydrofuran / 20 °C / Irradiation

With 2,6-di-tert-butyl-4-methyl-phenol; boron trifluoride diethyl etherate; boron tribromide; potassium carbonate; caesium carbonate; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;
DOI:10.1002/chem.201202498

Reference yield:

: 203438-46-4
1-(4-(4-hydroxyphenyl)-5,6-dihydropyridin-1(2H)-yl)ethanone

: 1425732-63-3
1-(4-(4-(3-(4-(1-acetyl-4-(4-(3-chloropropoxy)phenyl)piperidin-4-yl)phenoxy)propoxy)-2-methoxyphenyl)-4-(4-hydroxyphenyl)piperidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 6.5 h / Inert atmosphere; Reflux

2: boron trifluoride diethyl etherate / dichloromethane / 216 h / 20 °C / Darkness

3: caesium carbonate / acetone / 40 °C

4: 2,6-di-tert-butyl-4-methyl-phenol / tetrahydrofuran / 20 °C / Irradiation

With 2,6-di-tert-butyl-4-methyl-phenol; boron trifluoride diethyl etherate; potassium carbonate; caesium carbonate; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;
DOI:10.1002/chem.201202498