(1R,3S,4S,5S,1'S)-(+)-4-acetyloxy-3-(1'-hydroxy-1'-methoxycarbonyl-1'-<(R)-α-methylbenzylaminomethyl>methyl)-1-methoxycarbonylbicyclo<3.1.0>hexane

Base Information

Chemical Name:(1R,3S,4S,5S,1'S)-(+)-4-acetyloxy-3-(1'-hydroxy-1'-methoxycarbonyl-1'-<(R)-α-methylbenzylaminomethyl>methyl)-1-methoxycarbonylbicyclo<3.1.0>hexane
CAS No.:172214-85-6
Molecular Formula:C₂₂H₂₉NO₇
Molecular Weight:419.475
Hs Code.:

Synonyms:(1R,3S,4S,5S,1'S)-(+)-4-acetyloxy-3-(1'-hydroxy-1'-methoxycarbonyl-1'-<(R)-α-methylbenzylaminomethyl>methyl)-1-methoxycarbonylbicyclo<3.1.0>hexane

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Chemical Property of (1R,3S,4S,5S,1'S)-(+)-4-acetyloxy-3-(1'-hydroxy-1'-methoxycarbonyl-1'-<(R)-α-methylbenzylaminomethyl>methyl)-1-methoxycarbonylbicyclo<3.1.0>hexane

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Technology Process of (1R,3S,4S,5S,1'S)-(+)-4-acetyloxy-3-(1'-hydroxy-1'-methoxycarbonyl-1'-<(R)-α-methylbenzylaminomethyl>methyl)-1-methoxycarbonylbicyclo<3.1.0>hexane

There total 8 articles about (1R,3S,4S,5S,1'S)-(+)-4-acetyloxy-3-(1'-hydroxy-1'-methoxycarbonyl-1'-<(R)-α-methylbenzylaminomethyl>methyl)-1-methoxycarbonylbicyclo<3.1.0>hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 172214-83-4
(1R,3S,4S,5S,1'S)-(+)-4-acetyloxy-3-(1',2'-epoxy-ethyl-1'-methocarbonyl)-1-methoxycarbonylbicyclo<3.1.0.>hexane

: 172214-85-6
(1R,3S,4S,5S,1'S)-(+)-4-acetyloxy-3-(1'-hydroxy-1'-methoxycarbonyl-1'-<(R)-α-methylbenzylaminomethyl>methyl)-1-methoxycarbonylbicyclo<3.1.0>hexane

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃; for 1h;
DOI:10.1016/0957-4166(95)00233-F

Reference yield:

: 172214-80-1
(1S,5S,6S,7S,1'S)-(+)-6-acetyloxy-2,3-diaza-7-(1',2'-epoxyethyl-1'-methoxycarbonyl)-1-methoxycarbonylbicyclo<3.3.0>oct-2-ene

: 172214-85-6
(1R,3S,4S,5S,1'S)-(+)-4-acetyloxy-3-(1'-hydroxy-1'-methoxycarbonyl-1'-<(R)-α-methylbenzylaminomethyl>methyl)-1-methoxycarbonylbicyclo<3.1.0>hexane

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / benzophenone / CH₂Cl₂ / 0.25 h / -20 °C / Irradiation

2: 83 percent / dimethylformamide / 24 h / 60 °C

With benzophenone; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(96)00454-5

Reference yield:

: 172214-78-7
(3S,4S,1'S)-(+)-4-(1',2'-epoxyethyl-1'-methoxycarbonyl)-3-hydroxycyclopent-1-ene-1-carboxylic acid methyl ester

: 172214-85-6
(1R,3S,4S,5S,1'S)-(+)-4-acetyloxy-3-(1'-hydroxy-1'-methoxycarbonyl-1'-<(R)-α-methylbenzylaminomethyl>methyl)-1-methoxycarbonylbicyclo<3.1.0>hexane

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / pyridine / CH₂Cl₂ / Ambient temperature

2: diethyl ether / 3 h / Ambient temperature

3: 100 percent / benzophenone / CH₂Cl₂ / 0.25 h / -20 °C / Irradiation

4: 83 percent / dimethylformamide / 24 h / 60 °C

With pyridine; benzophenone; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(96)00454-5