8-N-(3,5-dimethylphenyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyadenosine

Base Information

Chemical Name:8-N-(3,5-dimethylphenyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyadenosine
CAS No.:1367203-97-1
Molecular Formula:C₃₀H₅₀N₆O₃Si₂
Molecular Weight:598.936
Hs Code.:

Synonyms:8-N-(3,5-dimethylphenyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyadenosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-N-(3,5-dimethylphenyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyadenosine

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Technology Process of 8-N-(3,5-dimethylphenyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyadenosine

There total 3 articles about 8-N-(3,5-dimethylphenyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 108-69-0
3,5-dimethylaminoaniline

: 211676-15-2
8-bromo-3′,5′-O-bis(tert-butyldimethylsilyl)-2′-deoxyadenosine

: 1367203-97-1
8-N-(3,5-dimethylphenyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyadenosine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,2-dimethoxyethane; at 95 ℃;
DOI:10.1002/cbic.201100573

Reference yield:

: 14985-44-5,90968-89-1
8-bromo-2'-deoxyadenosine

: 1367203-97-1
8-N-(3,5-dimethylphenyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; 1H-imidazole / 16 h / 20 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,2-dimethoxyethane / 95 °C

With pyridine; 1H-imidazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,2-dimethoxyethane; 2: Buchwald-Hartwig cross-coupling;
DOI:10.1002/cbic.201100573

Reference yield:

: 958-09-8,7005-15-4
2'-deoxy-D-adenosine

: 1367203-97-1
8-N-(3,5-dimethylphenyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 3 steps

1: bromine / 16 h / 20 °C / pH 5 / aq. acetate buffer

2: pyridine; 1H-imidazole / 16 h / 20 °C / Inert atmosphere

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,2-dimethoxyethane / 95 °C

With pyridine; 1H-imidazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,2-dimethoxyethane; 3: Buchwald-Hartwig cross-coupling;
DOI:10.1002/cbic.201100573