Benzyl 2-(2-ethoxy-2-oxoethyl)-3-oxopyrrolidine-1-carboxylate

Base Information

Chemical Name:Benzyl 2-(2-ethoxy-2-oxoethyl)-3-oxopyrrolidine-1-carboxylate
CAS No.:219841-93-7
Molecular Formula:C16H19 N O5
Molecular Weight:305.331
Hs Code.:
DSSTox Substance ID:DTXSID401186459
Nikkaji Number:J1.039.951C
Mol file:219841-93-7.mol

Synonyms:219841-93-7;benzyl 2-(2-ethoxy-2-oxoethyl)-3-oxopyrrolidine-1-carboxylate;1-N-Cbz-2-ethoxycarbonylmethyl-3-oxo-pyrrolidine;SCHEMBL288165;DTXSID401186459;MFCD11111472;SB35488;CS-0342631;FT-0706004;benzyl2-(2-ethoxy-2-oxoethyl)-3-oxopyrrolidine-1-carboxylate;Ethyl 3-oxo-1-[(phenylmethoxy)carbonyl]-2-pyrrolidineacetate;1-(Benzyloxycarbonyl)-3-oxopyrrolidine-2-acetic acid ethyl ester;2-Pyrrolidineacetic acid,3-oxo-1-[(phenylmethoxy)carbonyl]-,ethyl ester;3-Oxo-1-[(phenylmethoxy)carbonyl]-2-pyrrolidineacetic acid ethyl ester

Suppliers and Price of Benzyl 2-(2-ethoxy-2-oxoethyl)-3-oxopyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
1-N-Cbz-2-ethoxycarbonylmethyl-3-oxo-pyrrolidine 98%
500mg
$ 549.00

Total 6 raw suppliers

Chemical Property of Benzyl 2-(2-ethoxy-2-oxoethyl)-3-oxopyrrolidine-1-carboxylate

Chemical Property:

Boiling Point:443.6±40.0 °C(Predicted)
PKA:-2.59±0.40(Predicted)
PSA：72.91000
Density:1.227±0.06 g/cm3(Predicted)
LogP:1.85770
XLogP3:1.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:305.12632271
Heavy Atom Count:22
Complexity:417

Purity/Quality:

97% ^*data from raw suppliers

1-N-Cbz-2-ethoxycarbonylmethyl-3-oxo-pyrrolidine 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC1C(=O)CCN1C(=O)OCC2=CC=CC=C2

Technology Process of Benzyl 2-(2-ethoxy-2-oxoethyl)-3-oxopyrrolidine-1-carboxylate

There total 3 articles about Benzyl 2-(2-ethoxy-2-oxoethyl)-3-oxopyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[Benzyloxycarbonyl-(2-ethoxycarbonyl-ethyl)-amino]-succinic acid diethyl ester

: 219841-93-7
benzyl 2-(2-ethoxy-2-oxoethyl)-3-oxopyrrolidine-1-carboxylate

Guidance literature:: With sodium chloride; In dimethyl sulfoxide; Yield given;
DOI:10.1055/s-1998-1966

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 219841-93-7
benzyl 2-(2-ethoxy-2-oxoethyl)-3-oxopyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / NaHCO₃, H₂O / dioxane

2: NaH / toluene

3: brine / dimethylsulfoxide

With water; sodium hydride; sodium hydrogencarbonate; sodium chloride; In 1,4-dioxane; dimethyl sulfoxide; toluene;
DOI:10.1055/s-1998-1966

Reference yield:

: 161617-96-5
3-Benzyloxycarbonylamino-propionic acid ethyl ester

: 219841-93-7
benzyl 2-(2-ethoxy-2-oxoethyl)-3-oxopyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / toluene

2: brine / dimethylsulfoxide

With sodium hydride; sodium chloride; In dimethyl sulfoxide; toluene;
DOI:10.1055/s-1998-1966