Benzenemethanol, alpha-[[methyl(phenylmethyl)amino]methyl]-, acetate (ester), (R)-

Base Information

Chemical Name:Benzenemethanol, alpha-[[methyl(phenylmethyl)amino]methyl]-, acetate (ester), (R)-
CAS No.:118162-22-4
Molecular Formula:C₁₈H₂₁NO₂
Molecular Weight:283.37
Hs Code.:
DSSTox Substance ID:DTXSID501137574

Synonyms:DTXSID501137574;Benzenemethanol, alpha-[[methyl(phenylmethyl)amino]methyl]-, acetate (ester), (R)-;118162-22-4

Suppliers and Price of Benzenemethanol, alpha-[[methyl(phenylmethyl)amino]methyl]-, acetate (ester), (R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzenemethanol, alpha-[[methyl(phenylmethyl)amino]methyl]-, acetate (ester), (R)-

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:283.157228913
Heavy Atom Count:21
Complexity:306

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)OC(CN(C)CC1=CC=CC=C1)C2=CC=CC=C2
Isomeric SMILES:CC(=O)O[C@@H](CN(C)CC1=CC=CC=C1)C2=CC=CC=C2

Technology Process of Benzenemethanol, alpha-[[methyl(phenylmethyl)amino]methyl]-, acetate (ester), (R)-

There total 6 articles about Benzenemethanol, alpha-[[methyl(phenylmethyl)amino]methyl]-, acetate (ester), (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 118205-84-8
(R)-O-acetyl-N-(2-iodobenzyl)-N-methyl-β-(2-iodophenyl)ethanolamine

: 118162-22-4
Acetic acid (R)-2-(benzyl-methyl-amino)-1-phenyl-ethyl ester

: 118205-87-1
(8R)-acetoxy-6-methyl-5,6,7,8-tetrahydrodibenzazocine

Guidance literature:: With nickel; In N,N-dimethyl-formamide; at 55 ℃; for 9.5h;
DOI:10.1002/jhet.5570250123

Reference yield:

: 26260-02-6
2-iodobenzaldehyde

: 118162-22-4
Acetic acid (R)-2-(benzyl-methyl-amino)-1-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1) NaHCO₃, 2) NaBH₄ / 1) ethanol, reflux, 2 h, 2) reflux, 2 h

2: 1) boric acid, 2) NaBH₄ / 1) CH₃OH, r.t., 5 min, 2) 30 min

3: 1) (+)-diisopropyl tartrate, titanium tetraisopropoxide, 2) 3M-t-butyl hydroperoxide / 1) CH₂Cl₂, r.t., 30 min, 2) toluene, cooling, 2 h

4: 76 percent / 48 h / Ambient temperature

5: 11 percent / zero-valent nickel / dimethylformamide / 9.5 h / 55 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium tetrahydroborate; L-(+)-diisopropyl tartrate; boric acid; nickel; sodium hydrogencarbonate; In N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570250123

Reference yield:

: 118162-19-9
N-(2-iodobenzyl)-β-(2-iodophenyl)ethanolamine

: 118162-22-4
Acetic acid (R)-2-(benzyl-methyl-amino)-1-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1) boric acid, 2) NaBH₄ / 1) CH₃OH, r.t., 5 min, 2) 30 min

2: 1) (+)-diisopropyl tartrate, titanium tetraisopropoxide, 2) 3M-t-butyl hydroperoxide / 1) CH₂Cl₂, r.t., 30 min, 2) toluene, cooling, 2 h

3: 76 percent / 48 h / Ambient temperature

4: 11 percent / zero-valent nickel / dimethylformamide / 9.5 h / 55 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium tetrahydroborate; L-(+)-diisopropyl tartrate; boric acid; nickel; In N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570250123